Carla Prezioso1,2, Marijke Van Ghelue3,4, Ugo Moens5, Valeria Pietropaolo6. 1. Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy. 2. Microbiology of Chronic Neuro-Degenerative Pathologies, IRCSS San Raffaele Pisana, Rome, Italy. 3. Department of Medical Genetics, Division of Child and Adolescent Health, University Hospital of North Norway, Tromsø, Norway. 4. Department of Clinical Medicine Faculty of Health Sciences, University of Tromsø - The Arctic University of Norway, Tromsø, Norway. 5. Department of Medical Biology, Faculty of Health Sciences, University of Tromsø - The Arctic University of Norway, Tromsø, Norway. ugo.moens@uit.no. 6. Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy. valeria.pietropaolo@uniroma1.it.
Abstract
BACKGROUND: Human polyomavirus 6 (HPyV6) and HPyV7 are two of the novel polyomaviruses that were originally detected in non-diseased skin. Serological studies have shown that these viruses are ubiquitous in the healthy adult population with seroprevalence up to 88% for HPyV6 and 72% for HPyV7. Both viruses are associated with pruritic skin eruption in immunocompromised patients, but a role with other diseases in immunoincompetent patients or malignancies has not been established. METHODS: PCR was used to determine the presence of HPyV6 and HPyV7 DNA in urine samples from systemic lupus erythematosus (n = 73), multiple sclerosis (n = 50), psoriasis vulgaris (n = 15), arthritic psoriasis (n = 15) and HIV-positive patients (n = 66). In addition, urine from pregnant women (n = 47) and healthy blood donors (n = 20) was investigated. RESULTS: HPyV6 DNA was detected in 21 (28.8%) of the urine specimens from SLE patients, in 6 (9.1%) of the urine samples from the HIV-positive cohort, and in 19 (40.4%) samples from pregnant women. HPyV7 DNA was only found in 6 (8.2%) of the urine specimens from SLE patients and in 4 (8.5%) samples from pregnant women. No HPyV6 and HPyV7 viruria was detected in the urine samples from the other patients. CONCLUSIONS: HPyV6, and to a lesser extend HPyV7, viruria seems to be common in SLE and HIV-positive patients, and pregnant women. Whether these viruses are of clinical relevance in these patients is not known.
BACKGROUND:Human polyomavirus 6 (HPyV6) and HPyV7 are two of the novel polyomaviruses that were originally detected in non-diseased skin. Serological studies have shown that these viruses are ubiquitous in the healthy adult population with seroprevalence up to 88% for HPyV6 and 72% for HPyV7. Both viruses are associated with pruritic skin eruption in immunocompromised patients, but a role with other diseases in immunoincompetent patients or malignancies has not been established. METHODS: PCR was used to determine the presence of HPyV6 and HPyV7 DNA in urine samples from systemic lupus erythematosus (n = 73), multiple sclerosis (n = 50), psoriasis vulgaris (n = 15), arthritic psoriasis (n = 15) and HIV-positive patients (n = 66). In addition, urine from pregnant women (n = 47) and healthy blood donors (n = 20) was investigated. RESULTS:HPyV6 DNA was detected in 21 (28.8%) of the urine specimens from SLEpatients, in 6 (9.1%) of the urine samples from the HIV-positive cohort, and in 19 (40.4%) samples from pregnant women. HPyV7 DNA was only found in 6 (8.2%) of the urine specimens from SLEpatients and in 4 (8.5%) samples from pregnant women. No HPyV6 and HPyV7 viruria was detected in the urine samples from the other patients. CONCLUSIONS:HPyV6, and to a lesser extend HPyV7, viruria seems to be common in SLE and HIV-positive patients, and pregnant women. Whether these viruses are of clinical relevance in these patients is not known.
Authors: Anne M Gaynor; Michael D Nissen; David M Whiley; Ian M Mackay; Stephen B Lambert; Guang Wu; Daniel C Brennan; Gregory A Storch; Theo P Sloots; David Wang Journal: PLoS Pathog Date: 2007-05-04 Impact factor: 6.823
Authors: Christopher B Buck; Koenraad Van Doorslaer; Alberto Peretti; Eileen M Geoghegan; Michael J Tisza; Ping An; Joshua P Katz; James M Pipas; Alison A McBride; Alvin C Camus; Alexa J McDermott; Jennifer A Dill; Eric Delwart; Terry F F Ng; Kata Farkas; Charlotte Austin; Simona Kraberger; William Davison; Diana V Pastrana; Arvind Varsani Journal: PLoS Pathog Date: 2016-04-19 Impact factor: 6.823
Authors: Jacek Furmaga; Marek Kowalczyk; Tomasz Zapolski; Olga Furmaga; Leszek Krakowski; Grzegorz Rudzki; Andrzej Jaroszyński; Andrzej Jakubczak Journal: Viruses Date: 2021-07-30 Impact factor: 5.048