Gitishree Das1, Han-Seung Shin2, Estefânia V Ramos Campos3, Leonardo Fernandes Fraceto4, Maria Del Pilar Rodriguez-Torres5, Kelli Cristina Freitas Mariano3, Daniele Ribeiro de Araujo3, Fabián Fernández-Luqueño6, Renato Grillo7, Jayanta Kumar Patra8. 1. Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea. 2. Department of Food Science & Biotechnology, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea. 3. Human and Natural Sciences Center, Federal University of ABC. Av. Dos Estados, 5001. Bl. A, T3, Lab. 503-3. Bangú, Santo André, SP, Brazil. 4. Institute of Science and Technology of Sorocaba, São Paulo State University (UNESP), Av. Três de março, 511, Alto da Boa Vista, Sorocaba, São Paulo, 18087-180, Brazil. 5. Departamento de Ingenieria Molecular de Materiales, Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Blvd. Juriquilla 3001, 76230, Queretaro, Qro, Mexico. 6. Sustainability of Natural Resources and Energy Programs, Cinvestav-Saltillo, 25900, Coahuila, C.P., Mexico. 7. Department of Physics and Chemistry, São Paulo State University (UNESP), Avenida Brasil, 56, Centro, Ilha Solteira, SP, 15385-000, Brazil. 8. Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea. jkpatra.cet@gmail.com.
Abstract
BACKGROUND: The advances in products based on nanotechnology have directed extensive research on low-cost, biologically compatible, and easily degradable materials. MAIN BODY: Sericin (SER) is a protein mainly composed of glycine, serine, aspartic acid, and threonine amino acids removed from the silkworm cocoon (particularly Bombyx mori and other species). SER is a biocompatible material with economic viability, which can be easily functionalized due to its potential crosslink reactions. Also, SER has inherent biological properties, which makes possible its use as a component of pharmaceutical formulations with several biomedical applications, such as anti-tumor, antimicrobials, antioxidants and as scaffolds for tissue repair as well as participating in molecular mechanisms attributed to the regulation of transcription factors, reduction of inflammatory signaling molecules, stimulation of apoptosis, migration, and proliferation of mesenchymal cells. CONCLUSION: In this review, the recent innovations on SER-based nano-medicines (nanoparticles, micelles, films, hydrogels, and their hybrid systems) and their contributions for non-conventional therapies are discussed considering different molecular mechanisms for promoting their therapeutic applications.
BACKGROUND: The advances in products based on nanotechnology have directed extensive research on low-cost, biologically compatible, and easily degradable materials. MAIN BODY: Sericin (SER) is a protein mainly composed of glycine, serine, aspartic acid, and threonine amino acids removed from the silkworm cocoon (particularly Bombyx mori and other species). SER is a biocompatible material with economic viability, which can be easily functionalized due to its potential crosslink reactions. Also, SER has inherent biological properties, which makes possible its use as a component of pharmaceutical formulations with several biomedical applications, such as anti-tumor, antimicrobials, antioxidants and as scaffolds for tissue repair as well as participating in molecular mechanisms attributed to the regulation of transcription factors, reduction of inflammatory signaling molecules, stimulation of apoptosis, migration, and proliferation of mesenchymal cells. CONCLUSION: In this review, the recent innovations on SER-based nano-medicines (nanoparticles, micelles, films, hydrogels, and their hybrid systems) and their contributions for non-conventional therapies are discussed considering different molecular mechanisms for promoting their therapeutic applications.
Entities:
Keywords:
Biomaterials; Biomedical; Drug delivery; Nanoformulation; Sericin; Silk protein
Authors: Gyu Sang Sim; Nitheesha Shaji; P Santhoshkumar; Jae Woo Park; Chang Won Ho; Murugan Nanthagopal; Hong Ki Kim; Chang Woo Lee Journal: Nanomaterials (Basel) Date: 2022-03-31 Impact factor: 5.076