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Literature DB >> 33482473

Calcineurin: A star is reborn.

Abstract

The protein phosphatase calcineurin has long been familiar to the calcium community, but the definition of its physiological substrates has been far from complete. A new study rectifies this deficiency and sets the stage for new insights into the role of calcineurin in diverse cellular processes.

Entities: Chemical

Keywords: Calcineurin; Docking motif; LxVP; Phage display; PxIxIT; SLiM; Substrate

Mesh：

Substances：

Year: 2021 PMID： 33482473 PMCID： PMC8769354 DOI： 10.1016/j.ceca.2020.102324

Source DB: PubMed Journal: Cell Calcium ISSN： 0143-4160 Impact factor: 6.817

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References

14 in total

1. A second calcineurin binding site on the NFAT regulatory domain.

Authors: S Park; M Uesugi; G L Verdine
Journal: Proc Natl Acad Sci U S A Date: 2000-06-20 Impact factor: 11.205

2. Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding peptides.

Authors: Urs Wiedemann; Prisca Boisguerin; Rainer Leben; Dietmar Leitner; Gerd Krause; Karin Moelling; Rudolf Volkmer-Engert; Hartmut Oschkinat
Journal: J Mol Biol Date: 2004-10-22 Impact factor: 5.469

3. Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.

Authors: J Aramburu; F Garcia-Cózar; A Raghavan; H Okamura; A Rao; P G Hogan
Journal: Mol Cell Date: 1998-04 Impact factor: 17.970

4. Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling.

Authors: Callie P Wigington; Jagoree Roy; Nikhil P Damle; Vikash K Yadav; Cecilia Blikstad; Eduard Resch; Cassandra J Wong; Douglas R Mackay; Jennifer T Wang; Izabella Krystkowiak; Devin A Bradburn; Eirini Tsekitsidou; Su Hyun Hong; Malika Amyn Kaderali; Shou-Ling Xu; Tim Stearns; Anne-Claude Gingras; Katharine S Ullman; Ylva Ivarsson; Norman E Davey; Martha S Cyert
Journal: Mol Cell Date: 2020-07-08 Impact factor: 17.970

Calcineurin: A star is reborn.

1. A second calcineurin binding site on the NFAT regulatory domain.

2. Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding peptides.

3. Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.

4. Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling.

Review 5. Interaction of calcineurin with substrates and targeting proteins.

6. A conserved docking site modulates substrate affinity for calcineurin, signaling output, and in vivo function.

7. Leveraging New Definitions of the LxVP SLiM To Discover Novel Calcineurin Regulators and Substrates.

8. Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

Review 9. Identifying New Substrates and Functions for an Old Enzyme: Calcineurin.

10. The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin.