Théo Delbove1,2,3, François Gueyffier4, Laurent Juillard5, Emilie Kalbacher5, Delphine Maucort-Boulch6, Patrice Nony4, Brigitte Grosgogeat1,2,7, Kerstin Gritsch1,2,3. 1. Laboratoire des Multimatériaux et Interfaces UMR CNRS 5615, Université Claude Bernard Lyon 1, Université de Lyon, Villeurbanne, France. 2. UFR d'Odontologie, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France. 3. Service d'Odontologie (Unité Fonctionnelle de Parodontologie), Hospices Civils de Lyon, Lyon, France. 4. Service de Pharmacotoxicologie-Unité de Pharmacologie Clinique et Essais Thérapeutiques (UPCET), Lyon, France. 5. Service de Néphrologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, /INSERM U1060 CARMEN Research Unit, Lyon, France. 6. Service de Biostatistiques, Hospices Civils de Lyon, Lyon, France. 7. Service d'Odontologie (Unité Fonctionnelle de Recherche Clinique), Hospices Civils de Lyon, Lyon, France.
Abstract
AIM: To assess the effect of periodontal treatment (PT) on glomerular filtration rate (GFR), systemic inflammation, or mortality in patients with chronic kidney disease (CKD). METHODS: A literature search was performed on PubMed and Web of Science databases on articles published until December 2019. The PRISMA guidelines were used throughout the manuscript. RESULTS: Of the total studies found, only 18 met the inclusion criteria; four retrospective and 14 prospective studies (including 3 randomized controlled trials-RCT). After PT, 3 studies investigated GFR, 2 found significant improvement; 11 (including 2 RCTs) investigated C-reactive protein levels, 9 found a significant improvement (including the 2 RCTs); 5 (including 3 RCTs) investigated Interleukine-6 level, 4 found a significant improvement (including 2 RCTs) and 2 studies evaluated mortality, one (retrospective study) found a significant difference. CONCLUSIONS: Within the limitations of the present study, PT seems to improve CKD status, especially by reducing the systemic inflammation. Further RCTs are needed to confirm the results and specifically assess the influence of different types of PT in CKD patients. Taking into consideration the ability of PT to prevent further tooth loss and denutrition, early management of periodontitis is extremely important in patients with impaired renal function.
AIM: To assess the effect of periodontal treatment (PT) on glomerular filtration rate (GFR), systemic inflammation, or mortality in patients with chronic kidney disease (CKD). METHODS: A literature search was performed on PubMed and Web of Science databases on articles published until December 2019. The PRISMA guidelines were used throughout the manuscript. RESULTS: Of the total studies found, only 18 met the inclusion criteria; four retrospective and 14 prospective studies (including 3 randomized controlled trials-RCT). After PT, 3 studies investigated GFR, 2 found significant improvement; 11 (including 2 RCTs) investigated C-reactive protein levels, 9 found a significant improvement (including the 2 RCTs); 5 (including 3 RCTs) investigated Interleukine-6 level, 4 found a significant improvement (including 2 RCTs) and 2 studies evaluated mortality, one (retrospective study) found a significant difference. CONCLUSIONS: Within the limitations of the present study, PT seems to improve CKD status, especially by reducing the systemic inflammation. Further RCTs are needed to confirm the results and specifically assess the influence of different types of PT in CKDpatients. Taking into consideration the ability of PT to prevent further tooth loss and denutrition, early management of periodontitis is extremely important in patients with impaired renal function.
Authors: Marinella Ruospo; Suetonia C Palmer; Jonathan C Craig; Giorgio Gentile; David W Johnson; Pauline J Ford; Marcello Tonelli; Massimo Petruzzi; Michele De Benedittis; Giovanni F M Strippoli Journal: Nephrol Dial Transplant Date: 2013-09-29 Impact factor: 5.992
Authors: Cleber M de Souza; Ana Paula R Braosi; Sônia M Luczyszyn; Márcia Olandoski; Peter Kotanko; Ronald G Craig; Paula C Trevilatto; Roberto Pecoits-Filho Journal: J Periodontol Date: 2013-11-14 Impact factor: 6.993