BACKGROUND AND AIMS: Several studies reported a high incidence of pulmonary embolism (PE) among patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, but detailed data about clinical characteristics, risk factors of these patients and prognostic role of PE are still lacking. We aim to evaluate the occurrence of pulmonary embolism among patients with SARS-CoV-2 infection, and to describe their risk factors, clinical characteristics, and in-hospital clinical outcomes. METHODS: This is a multicenter Italian study including 333 consecutive SARS-CoV-2 patients admitted to seven hospitals from February 22 to May 15, 2020. All the patients underwent computed tomography pulmonary angiography (CTPA) for PE detection. In particular, CTPA was performed in case of inadequate response to high-flow oxygen therapy (Fi02≥0.4 to maintain Sp02≥92%), elevated D-dimer (>0.5μg/mL), or echocardiographic signs of right ventricular dysfunction. Clinical, laboratory and radiological data were also analyzed. RESULTS: Among 333 patients with laboratory confirmed SARS-CoV-2 pneumonia and undergoing CTPA, PE was detected in 109 (33%) cases. At CTPA, subsegmental, segmental, lobar and central thrombi were detected in 31 (29%), 50 (46%), 20 (18%) and 8 (7%) cases, respectively. In-hospital death occurred in 29 (27%) patients in the PE-group and in 47 (21%) patients in the non-PE group (p = 0.25). Patients in PE-group had a low rate of traditional risk factors and deep vein thrombosis was detected in 29% of patients undergoing compression ultrasonography. In 71% of cases with documented PE, the thrombotic lesions were located in the correspondence of parenchymal consolidation areas. CONCLUSIONS: Despite a low rate of risk factors for venous thromboembolism, PE is present in about 1 out 3 patients with SARS-CoV-2 pneumonia undergoing CTPA for inadequate response to oxygen therapy, elevated D-dimer level, or echocardiographic signs of right ventricular dysfunction. In most of the cases, the thromboses were located distally in the pulmonary tree and were mainly confined within pneumonia areas.
BACKGROUND AND AIMS: Several studies reported a high incidence of pulmonary embolism (PE) among patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, but detailed data about clinical characteristics, risk factors of these patients and prognostic role of PE are still lacking. We aim to evaluate the occurrence of pulmonary embolism among patients with SARS-CoV-2 infection, and to describe their risk factors, clinical characteristics, and in-hospital clinical outcomes. METHODS: This is a multicenter Italian study including 333 consecutive SARS-CoV-2patients admitted to seven hospitals from February 22 to May 15, 2020. All the patients underwent computed tomography pulmonary angiography (CTPA) for PE detection. In particular, CTPA was performed in case of inadequate response to high-flow oxygen therapy (Fi02≥0.4 to maintain Sp02≥92%), elevated D-dimer (>0.5μg/mL), or echocardiographic signs of right ventricular dysfunction. Clinical, laboratory and radiological data were also analyzed. RESULTS: Among 333 patients with laboratory confirmed SARS-CoV-2 pneumonia and undergoing CTPA, PE was detected in 109 (33%) cases. At CTPA, subsegmental, segmental, lobar and central thrombi were detected in 31 (29%), 50 (46%), 20 (18%) and 8 (7%) cases, respectively. In-hospital death occurred in 29 (27%) patients in the PE-group and in 47 (21%) patients in the non-PE group (p = 0.25). Patients in PE-group had a low rate of traditional risk factors and deep vein thrombosis was detected in 29% of patients undergoing compression ultrasonography. In 71% of cases with documented PE, the thrombotic lesions were located in the correspondence of parenchymal consolidation areas. CONCLUSIONS: Despite a low rate of risk factors for venous thromboembolism, PE is present in about 1 out 3 patients with SARS-CoV-2 pneumonia undergoing CTPA for inadequate response to oxygen therapy, elevated D-dimer level, or echocardiographic signs of right ventricular dysfunction. In most of the cases, the thromboses were located distally in the pulmonary tree and were mainly confined within pneumonia areas.
Authors: Saskia Middeldorp; Michiel Coppens; Thijs F van Haaps; Merijn Foppen; Alexander P Vlaar; Marcella C A Müller; Catherine C S Bouman; Ludo F M Beenen; Ruud S Kootte; Jarom Heijmans; Loek P Smits; Peter I Bonta; Nick van Es Journal: J Thromb Haemost Date: 2020-07-27 Impact factor: 5.824
Authors: Franck Nevesny; David C Rotzinger; Alexander W Sauter; Laura I Loebelenz; Lena Schmuelling; Hatem Alkadhi; Lukas Ebner; Andreas Christe; Alexandra Platon; Pierre-Alexandre Poletti; Salah D Qanadli Journal: Biomedicines Date: 2022-06-02
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Authors: José Antonio Rueda-Camino; Vanesa Sendín-Martín; María Dolores Joya-Seijo; María Angelina-García; Celia Zamarro-García; Francisco Javier Gimena-Rodríguez; Raquel Barba-Martín Journal: Med Clin (Engl Ed) Date: 2022-04-23
Authors: Scott C Woller; Kerstin de Wit; Helia Robert-Ebadi; Camila Masias; Frederikus A Klok; Paul L den Exter; Pierre-Emmanuel Morange; David Castelli; John-Bjarne Hansen Journal: Res Pract Thromb Haemost Date: 2022-08-26
Authors: Carlo Tacchetti; Antonio Esposito; Anna Palmisano; Davide Vignale; Edda Boccia; Alessandro Nonis; Chiara Gnasso; Riccardo Leone; Marco Montagna; Valeria Nicoletti; Antonello Giuseppe Bianchi; Stefano Brusamolino; Andrea Dorizza; Marco Moraschini; Rahul Veettil; Alberto Cereda; Marco Toselli; Francesco Giannini; Marco Loffi; Gianluigi Patelli; Alberto Monello; Gianmarco Iannopollo; Davide Ippolito; Elisabetta Maria Mancini; Gianluca Pontone; Luigi Vignali; Elisa Scarnecchia; Mario Iannacone; Lucio Baffoni; Massimiliano Sperandio; Caterina Chiara de Carlini; Sandro Sironi; Claudio Rapezzi; Luca Antiga; Veronica Jagher; Clelia Di Serio; Cesare Furlanello Journal: Radiol Med Date: 2022-08-29 Impact factor: 6.313
Authors: José Antonio Rueda-Camino; Vanesa Sendín-Martín; María Dolores Joya-Seijo; María Angelina-García; Celia Zamarro-García; Francisco Javier Gimena-Rodríguez; Raquel Barba-Martín Journal: Med Clin (Barc) Date: 2021-06-03 Impact factor: 1.725