Berna Evranos Ogmen1, Nagihan Ugurlu2, Sevgül Faki3, Sefika Burcak Polat4, Reyhan Ersoy4, Bekir Cakir4. 1. Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara Yildirim Beyazit University, Ankara Bilkent City Hospital, Üniversiteler Mh., Bilkent Blv, 06800, Ankara, Turkey. evranosberna@gmail.com. 2. Faculty of Medicine, Department of Ophthalmology, Ankara Yildirim Beyazit University, Ankara Bilkent City Hospital, Ankara, Turkey. 3. Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Ankara, Turkey. 4. Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara Yildirim Beyazit University, Ankara Bilkent City Hospital, Üniversiteler Mh., Bilkent Blv, 06800, Ankara, Turkey.
Abstract
PURPOSE: Prolactinoma is a type of pituitary tumour that produces an excessive amount of the hormone prolactin. It is the most common type of hormonally-active pituitary tumour. These tumours can cause ocular complications such as vision loss and visual fields (VF) defect. In this study, we aimed to evaluate the thickness of chorioretinal layers in patients with prolactinoma. METHODS: We enrolled 63 eyes of 32 prolactinoma patients and 36 eyes of 18 age and gender-matched healthy controls. All participants underwent complete hormonal and ophthalmological examination, including spectral-domain optical coherence tomography (SD-OCT) and VF test.The complete biochemical response was defined as serum PRL concentration ≤ 20 ng/mL at the time of evaluation.The seven layers were retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), and retinal pigment epithelium (RPE). The results of prolactinoma patients were compared with the control group. RESULTS: The mean RNFL, GCL, IPL, INL, ONL, and RPE were thinner in prolactinoma patients than the control group (p < 0.05) while OPL was similar between groups (p > 0.05).None of the patients had VF defect.The thickness of retinal layers was similar in patients with and without complete biochemical response (p > 0.05). CONCLUSION: To our knowledge, this is the first study that evaluates the thickness of chorioretinal layers in patients with prolactinoma.Most of the layers were thinner than the control group.Therefore, detailed eye assessment should be a routine component of the follow-up visits of prolactinoma patients and further studies related to this condition are required.
PURPOSE:Prolactinoma is a type of pituitary tumour that produces an excessive amount of the hormone prolactin. It is the most common type of hormonally-active pituitary tumour. These tumours can cause ocular complications such as vision loss and visual fields (VF) defect. In this study, we aimed to evaluate the thickness of chorioretinal layers in patients with prolactinoma. METHODS: We enrolled 63 eyes of 32 prolactinomapatients and 36 eyes of 18 age and gender-matched healthy controls. All participants underwent complete hormonal and ophthalmological examination, including spectral-domain optical coherence tomography (SD-OCT) and VF test.The complete biochemical response was defined as serum PRL concentration ≤ 20 ng/mL at the time of evaluation.The seven layers were retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), and retinal pigment epithelium (RPE). The results of prolactinomapatients were compared with the control group. RESULTS: The mean RNFL, GCL, IPL, INL, ONL, and RPE were thinner in prolactinomapatients than the control group (p < 0.05) while OPL was similar between groups (p > 0.05).None of the patients had VF defect.The thickness of retinal layers was similar in patients with and without complete biochemical response (p > 0.05). CONCLUSION: To our knowledge, this is the first study that evaluates the thickness of chorioretinal layers in patients with prolactinoma.Most of the layers were thinner than the control group.Therefore, detailed eye assessment should be a routine component of the follow-up visits of prolactinomapatients and further studies related to this condition are required.
Authors: Helen V Danesh-Meyer; Stuart C Carroll; Rod Foroozan; Peter J Savino; Jennifer Fan; Yannan Jiang; Stephen Vander Hoorn Journal: Invest Ophthalmol Vis Sci Date: 2006-11 Impact factor: 4.799
Authors: Jennifer K Sun; Michael M Lin; Jan Lammer; Sonja Prager; Rutuparna Sarangi; Paolo S Silva; Lloyd Paul Aiello Journal: JAMA Ophthalmol Date: 2014-11 Impact factor: 7.389