Literature DB >> 33479658

Synthesis and 18F-radiolabeling of thymidine AMBF3 conjugates.

Antonio A W L Wong1, Jerome Lozada1, Mathieu L Lepage1, Chengcheng Zhang2, Helen Merkens2, Jutta Zeisler2, Kuo-Shyan Lin2, François Bénard2, David M Perrin1.   

Abstract

In pursuit of 18F-labeled nucleosides for positron emission tomography (PET) imaging, we report on the chemical and radiochemical synthesis of two thymidine (dT) analogs, dT-C5-AMBF3 and dT-N3-AMBF3, that are radiofluorinated by isotope exchange (IEX) and studied as PET imaging agents in mice with tumor xenografts. dT-C5-AMBF3 shows preferential, and tumor-specific, uptake over dT-N3-AMBF3. This work provides a new synthetic method in order to access new nucleoside tracers for PET imaging. This journal is © The Royal Society of Chemistry 2020.

Entities:  

Year:  2020        PMID： 33479658      PMCID： PMC7578706          DOI： 10.1039/d0md00054j

Source DB:  PubMed          Journal:  RSC Med Chem        ISSN： 2632-8682


  43 in total

1.  Radiosynthesis of 3'-deoxy-3'-[(18)F]fluorothymidine: [(18)F]FLT for imaging of cellular proliferation in vivo.

Authors:  J R Grierson; A F Shields
Journal:  Nucl Med Biol       Date:  2000-02       Impact factor: 2.408

2.  18F-labeling of peptides by means of an organosilicon-based fluoride acceptor.

Authors:  Ralf Schirrmacher; Gerrit Bradtmöller; Esther Schirrmacher; Oliver Thews; Julia Tillmanns; Thomas Siessmeier; Hans G Buchholz; Peter Bartenstein; Björn Wängler; Christof M Niemeyer; Klaus Jurkschat
Journal:  Angew Chem Int Ed Engl       Date:  2006-09-11       Impact factor: 15.336

Review 3.  RGD-based PET tracers for imaging receptor integrin αv β3 expression.

Authors:  Hancheng Cai; Peter S Conti
Journal:  J Labelled Comp Radiopharm       Date:  2013-02-16       Impact factor: 1.921

4.  Synthesis and evaluation of (18)F-trifluoroborate derivatives of triphenylphosphonium for myocardial perfusion imaging.

Authors:  Zhengxing Zhang; Silvia Jenni; Chengcheng Zhang; Helen Merkens; Joseph Lau; Zhibo Liu; David M Perrin; François Bénard; Kuo-Shyan Lin
Journal:  Bioorg Med Chem Lett       Date:  2016-02-22       Impact factor: 2.823

Review 5.  Recent Advances in 18F Radiochemistry: A Focus on B-18F, Si-18F, Al-18F, and C-18F Radiofluorination via Spirocyclic Iodonium Ylides.

Authors:  Vadim Bernard-Gauthier; Mathieu L Lepage; Bjoern Waengler; Justin J Bailey; Steven H Liang; David M Perrin; Neil Vasdev; Ralf Schirrmacher
Journal:  J Nucl Med       Date:  2017-12-28       Impact factor: 10.057

6.  Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogs for boron neutron capture therapy of cancer.

Authors:  Hitesh K Agarwal; Ahmed Khalil; Keisuke Ishita; Weilian Yang; Robin J Nakkula; Lai-Chu Wu; Tehane Ali; Rohit Tiwari; Youngjoo Byun; Rolf F Barth; Werner Tjarks
Journal:  Eur J Med Chem       Date:  2015-05-27       Impact factor: 6.514

7.  Synthesis and evaluation of nucleoside radiotracers for imaging proliferation.

Authors:  Graham Smith; Roberta Sala; Laurence Carroll; Kevin Behan; Matthias Glaser; Edward Robins; Quang-Dé Nguyen; Eric O Aboagye
Journal:  Nucl Med Biol       Date:  2012-02-10       Impact factor: 2.408

8.  An azide-modified nucleoside for metabolic labeling of DNA.

Authors:  Anne B Neef; Nathan W Luedtke
Journal:  Chembiochem       Date:  2014-03-18       Impact factor: 3.164

9.  Melanoma Imaging Using 18F-Labeled α-Melanocyte-Stimulating Hormone Derivatives with Positron Emission Tomography.

Authors:  Chengcheng Zhang; Zhengxing Zhang; Kuo-Shyan Lin; Joseph Lau; Jutta Zeisler; Nadine Colpo; David M Perrin; François Bénard
Journal:  Mol Pharm       Date:  2018-05-10       Impact factor: 4.939

10.  Serological thymidine kinase 1 is a biomarker for early detection of tumours--a health screening study on 35,365 people, using a sensitive chemiluminescent dot blot assay.

Authors:  Zhi Heng Chen; Shou Qing Huang; Yande Wang; Ai Zhen Yang; Jian Wen; Xiao Hong Xu; Yan Chen; Qu Bo Chen; Ying Hong Wang; Ellen He; Ji Zhou; Sven Skog
Journal:  Sensors (Basel)       Date:  2011-11-28       Impact factor: 3.576
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  1 in total

Review 1.  Novel Approaches to Imaging the Pulmonary Vasculature and Right Heart.

Authors:  Fawaz Alenezi; Taylor A Covington; Monica Mukherjee; Stephen C Mathai; Paul B Yu; Sudarshan Rajagopal
Journal:  Circ Res       Date:  2022-04-28       Impact factor: 23.213
  1 in total

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