Literature DB >> 33479472

The relationships between LncRNA NNT-AS1, CRP, PCT and their interactions and the refractory mycoplasma pneumoniae pneumonia in children.

Ping Chen1,2, Zheng Huang3, Lumin Chen4, Shihao Zhuang5,6, Hongli Lin6, Jianfeng Xie3, Kuicheng Zheng3.   

Abstract

To investigate the relationships between LncRNA NNT-AS1, CRP, PCT and their interactions and the refractory mycoplasma pneumoniae pneumonia (RMPP) in children. Serum levels of LncRNA NNT-AS1 of RMPP and non-RMPP (NRMPP) patients were detected by real-time PCR, and were analyzed together with serum c-reactive protein (CRP) and procalcitonin (PCT). Correlations between LncRNA NNT-AS1 and CRP and PCT were analyzed by Pearson correlation test. The ROC curve was used to analyze the potential of LncRNA NNT-AS1, CRP and PCT as biomarkers for predicting RMPP. Logistic regression crossover model and the Excel compiled by Andersson et al. were used to analyze the interactions among the biomarkers. We found that LncRNA NNT-AS1, CRP and PCT were all highly expressed in patients with RMPP. LncRNA NNT-AS1 could positively correlate with the expressions of CRP and PCT, and jointly promote the occurrence of RMPP. The combined diagnosis of LncRNA NNT-AS1, CRP and PCT could predict the occurrence of RMPP.

Entities:  

Year:  2021        PMID： 33479472      PMCID： PMC7820231          DOI： 10.1038/s41598-021-81853-w

Source DB:  PubMed          Journal:  Sci Rep        ISSN： 2045-2322            Impact factor:   4.379


  30 in total

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7.  LncRNA NNT-AS1 is a major mediator of cisplatin chemoresistance in non-small cell lung cancer through MAPK/Slug pathway.

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Journal:  Eur Rev Med Pharmacol Sci       Date:  2018-08       Impact factor: 3.507

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Authors:  Shuren Guo; Xiaohuan Mao; Ming Liang
Journal:  Respir Res       Date:  2018-10-01
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  7 in total

1.  [Value of autotaxin in predicting refractory Mycoplasma pneumoniae pneumonia in children and its correlation with inflammatory cytokines].

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2.  Abnormal expression of lncRNA CASC9 in pneumonia children with respiratory failure and its feasible value for the clinical diagnosis of patients.

Authors:  Chi Zhou; Danfei Wu
Journal:  Cell Cycle       Date:  2022-05-19       Impact factor: 5.173

3.  Refractory Mycoplasma Pneumonia in Children: A Systematic Review and Meta-analysis of Laboratory Features and Predictors.

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Authors:  Chenglin Pan; Yanjie Chen; Shaosheng Wang; Ming Li; Shen Qu
Journal:  J Clin Lab Anal       Date:  2021-10-16       Impact factor: 2.352

5.  Development of a Nomogram for Predicting Refractory Mycoplasma pneumoniae Pneumonia in Children.

Authors:  Fangfang Shen; Chunjuan Dong; Tongqiang Zhang; Changjiang Yu; Kun Jiang; Yongsheng Xu; Jing Ning
Journal:  Front Pediatr       Date:  2022-02-25       Impact factor: 3.418

6.  Upregulated expression of long non-coding RNA MEG3 serves as a prognostic biomarker in severe pneumonia children and its regulatory mechanism.

Authors:  Jie Guo; Ning Zhang; Guozhi Liu; Aimei Zhang; Xin Liu; Jie Zheng
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269

7.  Changes in Serum CRP and PCT Levels in Patients with Acute Simple Lower Urinary Tract Infection and Evaluation of the Efficacy of Treatment with Shuangdong Capsules.

Authors:  Yachun Tang; Qun Zhou
Journal:  Emerg Med Int       Date:  2022-08-23       Impact factor: 1.621
  7 in total

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