| Literature DB >> 33478966 |
Melissa Harry1, Theo Woehrle2, Colleen Renier1, Margaret Furcht3, Michelle Enockson4.
Abstract
OBJECTIVES: To evaluate the predictive utility of the Activity Measure for Post-Acute Care '6-Clicks' daily activity and basic mobility functional assessment short forms on inpatient discharge to home compared with skilled nursing facilities, including by diagnostic group (trauma injury, major lower joint replacement/reattachment, spinal fusion excluding cervical), as well as assess the effect of the short forms on 30-day inpatient readmissions.Entities:
Keywords: occupational & industrial medicine; orthopaedic & trauma surgery; rehabilitation medicine
Year: 2021 PMID: 33478966 PMCID: PMC7825271 DOI: 10.1136/bmjopen-2020-044278
Source DB: PubMed Journal: BMJ Open ISSN: 2044-6055 Impact factor: 2.692
Figure 1Study inclusion and exclusion criteria flow chart.
Sample descriptive statistics by study cohort
| Pre-6-Clicks | Post-6-Clicks | |
| Unique patients | 10 316 | 10 931 |
| Female | 5436 (52.7%) | 5662 (51.8%) |
| Race | ||
| White | 9779 (94.8%) | 10 273 (94.0%) |
| American Indian | 377 (3.7%) | 446 (4.1%) |
| Black | 73 (0.7%) | 105 (1.0%) |
| Asian | 18 (0.2%) | 22 (0.2%) |
| Native Hawaiian/Pacific Islander | 14 (0.1%) | 15 (0.1%) |
| Unknown | 55 (0.5%) | 70 (0.6%) |
| Hispanic ethnicity | 34 (0.3%) | 50 (0.5%) |
| Unknown | 31 (0.3%) | 52 (0.5%) |
| Total hospitalisations per patient, n, Mdn, IQR, range | 12 314, 1, 1–1, 1–8 | 13 241, 1, 1–1, 1–8 |
| Hospitalisations per healthcare system hospital | ||
| Hospital 1 | 6210 (50.4%) | 6868 (51.9%) |
| Hospital 2 | 2897 (23.5%) | 3029 (22.9%) |
| Hospital 3 | 1854 (15.1%) | 2032 (15.3%) |
| Hospital 4 | 804 (6.5%) | 797 (6.0%) |
| Hospital 5 | 549 (4.5%) | 515 (3.9%) |
| Patient age at unique hospitalisation: Mdn, IQR, range | 72, 61–81, 18–106 | 71, 61–81, 18–104 |
| Length of stay in days: Mdn, IQR, range | 4, 2–6, 0–102 | 4, 2–6, 0–128 |
| Charlson Comorbidity Index score: Mdn, IQR, range | 0, 0–1, 0–12 | 0, 0–1, 0–14 |
| Prior admissions in study: Mdn, IQR, range | 0, 0–0, 0–7 | 0, 0–1, 0–10 |
| Prior admissions in past 30 days: Mdn, IQR, range | 0, 0–0, 0–3 | 0, 0–0, 0–3 |
| 30-day inpatient readmissions: Mdn, IQR, range | 0, 0–0, 0–5 | 0, 0–0, 0–4 |
| Hospitalisation cause | ||
| Traumatic injury* | 818 (6.6%) | 811 (6.1%) |
| Specific procedure | 2374 (19.3%) | 2446 (18.5%) |
| Spinal fusion except cervical | 215 (9.1%) | 267 (10.9%) |
| Major lower extremity joint replacement or reattachment | 2159 (90.9%) | 2179 (89.1%) |
| Other cause | 9190 (74.6%) | 10 072 (76.1%) |
| Discharge disposition | ||
| Home with or without services | 8366 (67.9%) | 9073 (68.5%) |
| Intermediate care facility/assisted living | 356 (2.9%) | 376 (2.8%) |
| Skilled nursing facilities/swing bed | 3544 (28.8%) | 3761 (28.4%) |
| Another healthcare institution | 48 (0.4%) | 31 (0.2%) |
| Daily activity 6-Clicks scale score: M (SD) | N/A | 42.56 (7.57) |
| Percent impairment: M (SD) | N/A | 37.02% (18.71) |
| Basic mobility 6-Clicks scale score: M (SD) | N/A | 48.34 (8.79) |
| Percent impairment: M (SD) | N/A | 32.66% (20.27) |
*Patients could have a traumatic hospitalisation associated with either a spinal fusion except cervical or a major lower extremity joint replacement or reattachment.
M, mean; Mdn, median; N/A, not applicable.
The predictive utility of the 6-Clicks daily activity and basic mobility scale scores in determining patient discharge home with or without services (including assisted living) versus discharge to skilled nursing facilities with randomly selected development and validation samples
| 6-Clicks Scale Score | n | AUC | 95% CI | Sens | Spec | PPV | NPV | R2* | R2† | χ2 (df)‡ | P value‡ | OR | 95% CI | P value |
| Daily activity | ||||||||||||||
| Development | 5523 | 0.84 | 0.83 to 0.85 | 0.721 | 0.797 | 0.781 | 0.741 | 0.27 | 0.39 | 57.91 (7) | <0.001 | 1.24 | 1.22 to 1.26 | <0.001 |
| Validation | 5531 | 0.85 | 0.84 to 0.86 | 0.693 | 0.837 | 0.809 | 0.732 | 0.30 | 0.42 | 35.24 (8) | <0.001 | 1.27 | 1.25 to 1.28 | <0.001 |
| Basic mobility | ||||||||||||||
| Development | 6267 | 0.87 | 0.86 to 0.88 | 0.760 | 0.823 | 0.811 | 0.774 | 0.32 | 0.45 | 50.97 (8) | <0.001 | 1.22 | 1.21 to 1.24 | <0.001 |
| Validation | 6271 | 0.87 | 0.86 to 0.88 | 0.749 | 0.824 | 0.810 | 0.766 | 0.32 | 0.46 | 54.39 (8) | <0.001 | 1.23 | 1.22 to 1.24 | <0.001 |
*Cox and Snell R2.
†Nagelkerke R2.
‡Hosmer-Lemeshow test.
AUC, area under the receiver operating characteristic curve; NPV, standardised negative predictive value; PPV, standardised positive predictive value.
Multivariate logistic regression models assessing predictive utility of 6-Clicks daily activity and basic mobility scale scores for discharge home with or without services (including assisted living) versus skilled nursing facilities*
| Models and groups | n | R2† | R2‡ | χ2 (df)§ | P Value§ | Daily activity | Basic mobility | ||||
| OR | 95% CI | P value | OR | 95% CI | P value | ||||||
| Full sample¶ | |||||||||||
| Daily activity | 7766 | 0.35 | 0.50 | 61.80 (8) | <0.001 | 1.26 | 1.24 to 1.27 | <0.001 | N/A | N/A | N/A |
| Basic mobility | 8734 | 0.35 | 0.52 | 29.40 (8) | <0.001 | N/A | N/A | N/A | 1.22 | 1.21 to 1.24 | <0.001 |
| Daily activity and basic mobility | 7321 | 0.39 | 0.57 | 54.57 (8) | <0.001 | 1.14 | 1.12 to 1.16 | <0.001 | 1.14 | 1.13 to 1.16 | <0.001 |
| Trauma** | |||||||||||
| Daily activity | 560 | 0.49 | 0.67 | 16.56 (8) | 0.035 | 1.33 | 1.25 to 1.41 | <0.001 | N/A | N/A | N/A |
| Basic mobility | 583 | 0.52 | 0.71 | 14.01 (8) | 0.082 | N/A | N/A | N/A | 1.30 | 1.23 to 1.37 | <0.001 |
| Daily activity and basic mobility | 535 | 0.55 | 0.76 | 7.68 (8) | 0.465 | 1.22 | 1.12 to 1.32 | <0.001 | 1.22 | 1.14 to 1.31 | <0.001 |
| Lower joint replacement or reattachment** | |||||||||||
| Daily activity | 1733 | 0.30 | 0.55 | 18.79 (8) | 0.016 | 1.51 | 1.42 to 1.61 | <0.001 | N/A | N/A | N/A |
| Basic mobility | 1813 | 0.34 | 0.64 | 7.90 (8) | 0.443 | N/A | N/A | N/A | 1.33 | 1.28 to 1.39 | <0.001 |
| Daily activity and basic mobility | 1731 | 0.37 | 0.68 | 2.90 (8) | 0.941 | 1.29 | 1.20 to 1.38 | <0.001 | 1.27 | 1.22 to 1.32 | <0.001 |
| Spinal fusion excluding cervical** | |||||||||||
| Daily activity | 238 | 0.43 | 0.70 | 2.83 (8) | 0.945 | 1.92 | 1.55 to 2.39 | <0.001 | N/A | N/A | N/A |
| Basic mobility | 228 | 0.45 | 0.72 | 46.48 (8) | <0.001 | N/A | N/A | N/A | 1.71 | 1.38 to 2.12 | <0.001 |
| Daily activity and basic mobility | 226 | 0.50 | 0.80 | 45.53 (8) | <0.001 | 1.59 | 1.24 to 2.03 | <0.001 | 1.47 | 1.20 to 1.80 | <0.001 |
*Events include first events only.
†Cox and Snell R2.
‡Nagelkerke R2.
§Hosmer-Lemeshow test.
¶Controlling for age, gender, race, Hispanic ethnicity, hospital, Charlson Comorbidity Index score, number of previous admissions in the study period (including in the pre-6-Clicks cohort), number of previous admissions in the last 30 days (including in the pre-6-Clicks cohort), primary diagnosis type (major lower extremity replacement or reattachment, spinal fusion except cervical, or other), and whether or not the hospitalisation was due to trauma.
**Controlling for age, gender, race, Hispanic ethnicity, hospital, Charlson Comorbidity Index score, number of previous admissions in the study period (including in the pre-6-Clicks cohort). Number of previous admissions in the last 30 days was excluded due to zero values in the diagnostic group analyses.
NA, not applicable.
The predictive utility of the 6-Clicks daily activity and basic mobility scale scores in determining patient discharge home with or without services (including assisted living) versus discharge to skilled nursing facilities by diagnostic group
| 6-Clicks Scale Score | n | AUC | 95% CI | Sens | Spec | PPV | NPV | R2* | R2† | χ2 (df)‡ | P value‡ | OR | 95% CI | P value |
| Trauma | ||||||||||||||
| Daily activity | 667 | 0.90 | 0.88 to 0.93 | 0.780 | 0.859 | 0.847 | 0.796 | 0.42 | 0.57 | 17.93 (7) | 0.012 | 1.38 | 1.31 to 1.45 | <0.001 |
| Basic mobility | 694 | 0.92 | 0.90 to 0.94 | 0.827 | 0.860 | 0.856 | 0.833 | 0.47 | 0.65 | 11.36 (8) | 0.182 | 1.35 | 1.29 to 1.42 | <0.001 |
| Major lower joint replacement or reattachment | ||||||||||||||
| Daily activity | 1990 | 0.82 | 0.79 to 0.85 | 0.823 | 0.884 | 0.876 | 0.833 | 0.18 | 0.32 | 7.35 (4) | 0.118 | 1.33 | 1.29 to 1.38 | <0.001 |
| Basic mobility | 2094 | 0.91 | 0.89 to 0.92 | 0.781 | 0.926 | 0.914 | 0.809 | 0.29 | 0.51 | 43.14 (5) | <0.001 | 1.35 | 1.31 to 1.39 | <0.001 |
| Spinal fusion except cervical | ||||||||||||||
| Daily activity | 260 | 0.92 | 0.88 to 0.97 | 0.794 | 0.912 | 0.900 | 0.816 | 0.36 | 0.59 | 7.98 (5) | 0.158 | 1.79 | 1.51 to 2.13 | <0.001 |
| Basic mobility | 250 | 0.94 | 0.90 to 0.97 | 0.811 | 0.920 | 0.910 | 0.829 | 0.39 | 0.62 | 11.18 (7) | 0.131 | 1.57 | 1.35 to 1.82 | <0.001 |
*Cox and Snell R2.
†Nagelkerke R2.
‡Hosmer-Lemeshow test.
AUC, area under the receiver operating characteristic curve; NPV, negative predictive value; PPV, positive predictive value; Sens, sensitivity; Spec, specificity.
Bivariate and multivariate generalised estimating equations: hospital 30-day postdischarge inpatient readmissions (yes/no) and counts by hospital and overall
| Models | 30-day hospitalisation yes/no* | 30-day inpatient readmission counts† | ||
| OR (95% CI) | P value | IRR (95% CI) | P value | |
| Hospital 1‡ | ||||
| Bivariate§ | 0.97 (0.87 to 1.08) | 0.561 | 0.94 (0.84 to 1.04) | 0.233 |
| Multivariate¶ | 0.92 (0.84 to 1.01)** | 0.065 | 0.90 (0.81 to 0.99)** | 0.030 |
| Hospital 2 | ||||
| Bivariate§ | 1.11 (0.95 to 1.30) | 0.201 | 1.12 (0.95 to 1.31) | 0.168 |
| Multivariate¶ | 1.02 (0.88 to 1.20)†† | 0.769 | 1.03 (0.89 to 1.19)†† | 0.727 |
| Hospital 3 | ||||
| Bivariate§ | 1.05 (0.83 to 1.32) | 0.704 | 1.01 (0.80 to 1.28) | 0.916 |
| Multivariate¶ | 1.01 (0.82 to 1.25) | 0.704 | 0.98 (0.81 to 1.18) | 0.814 |
| Hospital 4 | ||||
| Bivariate§ | 1.37 (0.99 to 1.91) | 0.060 | 1.47 (1.06 to 2.03) | 0.021 |
| Multivariate¶ | 1.28 (0.93 to 1.77)** | 0.129 | 1.37 (1.00 to 1.88)** | 0.048 |
| Hospital 5 | ||||
| Bivariate§ | 0.99 (0.68 to 1.45) | 0.976 | 0.98 (0.69 to 1.39) | 0.920 |
| Multivariate¶ | 0.87 (0.60 to 1.25)** | 0.448 | 0.88 (0.63 to 1.23)** | 0.460 |
| All Hospitals‡‡ | ||||
| Bivariate§ | 1.03 (0.95 to 1.12) | 0.444 | 1.01 (0.94 to 1.10) | 0.743 |
| Multivariate¶ | 0.96 (0.89 to 1.04)‡‡ | 0.324 | 0.96 (0.89 to 1.03)‡‡ | 0.220 |
*Negative binomial. All models had lower Quasi-likelihood under Independence Model Criterion (QIC) and Corrected Quasi-likelihood under Independence Model Criterion (QICC) than Poisson generalised estimating equations (not shown).
†Binary logit link.
‡The indicator variable for trauma patients was only included in multivariate models including Hospital 1.
§Compared to the pre-6-Clicks cohort.
¶Compared to the pre-6-Clicks cohort. Multivariate models also controlled for gender, race, Hispanic ethnicity, age, hospital, Charlson Comorbidity Index score, whether the admission was related to a trauma event, diagnosis type (major lower joint replacement or reattachment, spinal fusion excluding cervical, other), prior admissions in the study, and prior admissions in the last 30 days.
**Hispanic ethnicity and race removed from the model due singular Hessian matrices resulting in uncertainty of valid model fit or unexpected estimation error.
††Race removed from the model due to singular Hessian matrix or unexpected estimation error.
‡‡Hispanic ethnicity was removed from the model due to lack of convergence, singular Hessian matrix or unexpected estimation error.
IRR, incidence rate ratio.