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Literature DB >> 33478820

Demystifying Cell Cycle Arrest by HIV-1 Vif.

Abstract

Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle.

Entities: Chemical

Keywords: G2/M cell cycle arrest; HIV-1; PPP2R5; Vif; host–pathogen interaction

Mesh：

Substances：

Year: 2021 PMID： 33478820 PMCID： PMC8416294 DOI： 10.1016/j.tim.2021.01.001

Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079

23 in total

1. HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication.

Authors: Taisuke Izumi; Katsuhiro Io; Masashi Matsui; Kotaro Shirakawa; Masanobu Shinohara; Yuya Nagai; Masahiro Kawahara; Masayuki Kobayashi; Hiroshi Kondoh; Naoko Misawa; Yoshio Koyanagi; Takashi Uchiyama; Akifumi Takaori-Kondo
Journal: Proc Natl Acad Sci U S A Date: 2010-11-11 Impact factor: 11.205

2. Evolutionarily conserved pressure for the existence of distinct G2/M cell cycle arrest and A3H inactivation functions in HIV-1 Vif.

Authors: Ke Zhao; Juan Du; Yajuan Rui; Wenwen Zheng; Jian Kang; Jingwei Hou; Kang Wang; Wenyan Zhang; Viviana A Simon; Xiao-Fang Yu
Journal: Cell Cycle Date: 2015 Impact factor: 4.534

3. Human immunodeficiency virus type 1 Vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradation.

Authors: Jason L DeHart; Alberto Bosque; Reuben S Harris; Vicente Planelles
Journal: J Virol Date: 2008-07-02 Impact factor: 5.103

4. Structural basis of host protein hijacking in human T-cell leukemia virus integration.

Authors: Veer Bhatt; Ke Shi; Daniel J Salamango; Nicholas H Moeller; Krishan K Pandey; Sibes Bera; Thomas E Bohl; Fredy Kurniawan; Kayo Orellana; Wei Zhang; Duane P Grandgenett; Reuben S Harris; Anna C Sundborger-Lunna; Hideki Aihara
Journal: Nat Commun Date: 2020-06-19 Impact factor: 14.919

5. Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection.

Authors: Edward J D Greenwood; James C Williamson; Agata Sienkiewicz; Adi Naamati; Nicholas J Matheson; Paul J Lehner
Journal: Cell Rep Date: 2019-04-30 Impact factor: 9.423

Review 6. How SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest.

Authors: Marie-Lise Blondot; Loic Dragin; Hichem Lahouassa; Florence Margottin-Goguet
Journal: Retrovirology Date: 2014-12-11 Impact factor: 4.602

7. Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants.

Authors: Edward Jd Greenwood; Nicholas J Matheson; Kim Wals; Dick Jh van den Boomen; Robin Antrobus; James C Williamson; Paul J Lehner
Journal: Elife Date: 2016-09-30 Impact factor: 8.140

Demystifying Cell Cycle Arrest by HIV-1 Vif.

1. HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication.

2. Evolutionarily conserved pressure for the existence of distinct G2/M cell cycle arrest and A3H inactivation functions in HIV-1 Vif.

3. Human immunodeficiency virus type 1 Vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradation.

4. Structural basis of host protein hijacking in human T-cell leukemia virus integration.

5. Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection.

Review 6. How SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest.

7. Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants.

Review 8. Protein phosphatases in the regulation of mitosis.

9. HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

10. Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest.

1. Evolutionary Conservation of PP2A Antagonism and G2/M Cell Cycle Arrest in Maedi-Visna Virus Vif.

2. A Novel, Fully Spliced, Accessory Gene in Equine Lentivirus with Distinct Rev-Responsive Element.