Yuewei Liu1, Jingju Pan2, Chuangang Fan3, Ruijun Xu4, Yaqi Wang4, Chang Xu4, Shuguang Xie3, Hai Zhang3, Xiuqing Cui3, Zhe Peng3, Chunxiang Shi5, Yunquan Zhang6, Hong Sun7, Yun Zhou8, Lan Zhang9. 1. Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China. Electronic address: liuyuewei@mail.sysu.edu.cn. 2. Institute of Chronic Noncommunicable Disease Control and Prevention, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China. 3. Institute of Health Surveillance, Analysis and Protection, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China. 4. Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China. 5. Meteorological Data Laboratory, National Meteorological Information Center, Beijing, China. 6. Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan, China. 7. Department of Environmental and Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China. 8. State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou, China. 9. Institute of Chronic Noncommunicable Disease Control and Prevention, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China. Electronic address: hbcdczl@163.com.
Abstract
BACKGROUND: Short-term exposure to ambient air pollution has been linked to occurrence of myocardial infarction (MI); however, only a limited number of studies investigated its association with death from MI, and the results remain inconsistent. OBJECTIVES: This study sought to investigate the association of short-term exposure to air pollution across a wide range of concentrations with MI mortality. METHODS: A time-stratified case-crossover study was conducted to investigate 151,608 MI death cases in Hubei province (China) from 2013 to 2018. Based on each case's home address, exposure to particulate matter with an aerodynamic diameter ≤2.5 μm (PM2.5), particulate matter with an aerodynamic diameter ≤10 μm (PM10), sulfur dioxide, nitrogen dioxide (NO2), carbon monoxide, and ozone on each of the case and control days was assessed as the inverse distance-weighted average concentration at neighboring air quality monitoring stations. Conditional logistic regression models were implemented to quantify exposure-response associations. RESULTS: Exposure to PM2.5, PM10, and NO2 (mean exposure on the same day of death and 1 day prior) was significantly associated with increased odds of MI mortality. The odds associated with PM2.5 and PM10 exposures increased steeply before a breakpoint (PM2.5, 33.3 μg/m3; PM10, 57.3 μg/m3) and flattened out at higher exposure levels, while the association for NO2 exposure was almost linear. Each 10-μg/m3 increase in exposure to PM2.5 (<33.3 μg/m3), PM10 (<57.3 μg/m3), and NO2 was significantly associated with a 4.14% (95% confidence interval [CI]: 1.25% to 7.12%), 2.67% (95% CI: 0.80% to 4.57%), and 1.46% (95% CI: 0.76% to 2.17%) increase in odds of MI mortality, respectively. The association between NO2 exposure and MI mortality was significantly stronger in older adults. CONCLUSIONS: Short-term exposure to PM2.5, PM10, and NO2 was associated with increased risk of MI mortality.
BACKGROUND: Short-term exposure to ambient air pollution has been linked to occurrence of myocardial infarction (MI); however, only a limited number of studies investigated its association with death from MI, and the results remain inconsistent. OBJECTIVES: This study sought to investigate the association of short-term exposure to air pollution across a wide range of concentrations with MI mortality. METHODS: A time-stratified case-crossover study was conducted to investigate 151,608 MI death cases in Hubei province (China) from 2013 to 2018. Based on each case's home address, exposure to particulate matter with an aerodynamic diameter ≤2.5 μm (PM2.5), particulate matter with an aerodynamic diameter ≤10 μm (PM10), sulfur dioxide, nitrogen dioxide (NO2), carbon monoxide, and ozone on each of the case and control days was assessed as the inverse distance-weighted average concentration at neighboring air quality monitoring stations. Conditional logistic regression models were implemented to quantify exposure-response associations. RESULTS: Exposure to PM2.5, PM10, and NO2 (mean exposure on the same day of death and 1 day prior) was significantly associated with increased odds of MI mortality. The odds associated with PM2.5 and PM10 exposures increased steeply before a breakpoint (PM2.5, 33.3 μg/m3; PM10, 57.3 μg/m3) and flattened out at higher exposure levels, while the association for NO2 exposure was almost linear. Each 10-μg/m3 increase in exposure to PM2.5 (<33.3 μg/m3), PM10 (<57.3 μg/m3), and NO2 was significantly associated with a 4.14% (95% confidence interval [CI]: 1.25% to 7.12%), 2.67% (95% CI: 0.80% to 4.57%), and 1.46% (95% CI: 0.76% to 2.17%) increase in odds of MI mortality, respectively. The association between NO2 exposure and MI mortality was significantly stronger in older adults. CONCLUSIONS: Short-term exposure to PM2.5, PM10, and NO2 was associated with increased risk of MI mortality.
Authors: Omar Al-Mukhtar; Sara Vogrin; Edwin R Lampugnani; Samer Noaman; Diem T Dinh; Angela L Brennan; Christopher Reid; Jeffrey Lefkovits; Nicholas Cox; Dion Stub; William Chan Journal: J Am Heart Assoc Date: 2022-03-15 Impact factor: 6.106
Authors: Huan Li; Min Li; Shiyu Zhang; Zhengmin Min Qian; Zilong Zhang; Kai Zhang; Chongjian Wang; Lauren D Arnold; Stephen Edward McMillin; Shaowei Wu; Fei Tian; Hualiang Lin Journal: Sci Total Environ Date: 2022-01-04 Impact factor: 7.963
Authors: Haitong Zhe Sun; Pei Yu; Changxin Lan; Michelle W L Wan; Sebastian Hickman; Jayaprakash Murulitharan; Huizhong Shen; Le Yuan; Yuming Guo; Alexander T Archibald Journal: Innovation (Camb) Date: 2022-04-20