Sharon Rose Hill1, Tanvi Taparia2,3, Rickard Ignell2. 1. Disease Vector Group, Department of Plant Protection Biology, Swedish University of Agricultural Sciences, 230 54, Alnarp, Sweden. sharon.hill@slu.se. 2. Disease Vector Group, Department of Plant Protection Biology, Swedish University of Agricultural Sciences, 230 54, Alnarp, Sweden. 3. Business Unit Biointeractions and Plant Health, Wageningen University and Research, AA, 6700, Wageningen, The Netherlands.
Abstract
BACKGROUND: In the light of dengue being the fastest growing transmissible disease, there is a dire need to identify the mechanisms regulating the behaviour of the main vector Aedes aegypti. Disease transmission requires the female mosquito to acquire the pathogen from a blood meal during one gonotrophic cycle, and to pass it on in the next, and the capacity of the vector to maintain the disease relies on a sustained mosquito population. RESULTS: Using a comprehensive transcriptomic approach, we provide insight into the regulation of the odour-mediated host- and oviposition-seeking behaviours throughout the first gonotrophic cycle. We provide clear evidence that the age and state of the female affects antennal transcription differentially. Notably, the temporal- and state-dependent patterns of differential transcript abundance of chemosensory and neuromodulatory genes extends across families, and appears to be linked to concerted differential modulation by subsets of transcription factors. CONCLUSIONS: By identifying these regulatory pathways, we provide a substrate for future studies targeting subsets of genes across disparate families involved in generating key vector behaviours, with the goal to develop novel vector control tools.
BACKGROUND: In the light of dengue being the fastest growing transmissible disease, there is a dire need to identify the mechanisms regulating the behaviour of the main vector Aedes aegypti. Disease transmission requires the female mosquito to acquire the pathogen from a blood meal during one gonotrophic cycle, and to pass it on in the next, and the capacity of the vector to maintain the disease relies on a sustained mosquito population. RESULTS: Using a comprehensive transcriptomic approach, we provide insight into the regulation of the odour-mediated host- and oviposition-seeking behaviours throughout the first gonotrophic cycle. We provide clear evidence that the age and state of the female affects antennal transcription differentially. Notably, the temporal- and state-dependent patterns of differential transcript abundance of chemosensory and neuromodulatory genes extends across families, and appears to be linked to concerted differential modulation by subsets of transcription factors. CONCLUSIONS: By identifying these regulatory pathways, we provide a substrate for future studies targeting subsets of genes across disparate families involved in generating key vector behaviours, with the goal to develop novel vector control tools.
Authors: Henry J McQuillan; Andrew B Barron; Alison R Mercer Journal: J Comp Physiol A Neuroethol Sens Neural Behav Physiol Date: 2012-08-29 Impact factor: 1.836
Authors: Joanna K Konopka; Darya Task; Ali Afify; Joshua Raji; Katelynn Deibel; Sarah Maguire; Randy Lawrence; Christopher J Potter Journal: Chem Senses Date: 2021-01-01 Impact factor: 4.985