Literature DB >> 33477900

The Emerging Role of BDNF/TrkB Signaling in Cardiovascular Diseases.

Peng-Zhou Hang1,2, Hua Zhu1, Pei-Feng Li2, Jie Liu2, Feng-Qin Ge1, Jing Zhao3, Zhi-Min Du2,4.   

Abstract

Brain-derived neurotrophic factor (BDNF) is one of the most abundantneurotrophins in the central nervous system. Numerous studies suggestthat BDNF has extensive roles by binding to its specific receptor, tropomyosin-related kinase receptor B (TrkB), and thereby triggering downstream signaling pathways. Recently, growing evidence highlightsthat the BDNF/TrkB pathway is expressed in the cardiovascular system andclosely associated with the development and outcome of cardiovascular diseases (CVD), including coronary artery disease, heart failure, cardiomyopathy, hypertension, and metabolic diseases. Furthermore, circulating BDNF has also been revealed as a new potential biomarker for both diagnosis and prognosis of CVD. In this review, we discuss the current evidence of the emerging role of BDNF/TrkBsignalingand address the challenges that remain in translating these discoveries to novel therapeutic strategies for CVD.

Entities:  

Keywords:  biomarker; brain-derived neurotrophic factor; cardiovascular diseases; tropomyosin-related kinase receptor B

Year:  2021        PMID： 33477900      PMCID： PMC7833389          DOI： 10.3390/life11010070

Source DB:  PubMed          Journal:  Life (Basel)        ISSN： 2075-1729


  78 in total

Review 1.  Neurotrophin signalling in health and disease.

Authors:  Moses V Chao; Rithwick Rajagopal; Francis S Lee
Journal:  Clin Sci (Lond)       Date:  2006-02       Impact factor: 6.124

2.  7,8-Dihydroxyflavone attenuates TNF-α-induced skin aging in Hs68 human dermal fibroblast cells via down-regulation of the MAPKs/Akt signaling pathways.

Authors:  Ji Won Choi; Jisun Lee; Yong Il Park
Journal:  Biomed Pharmacother       Date:  2017-10-06       Impact factor: 6.529

3.  Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway.

Authors:  Sho Okada; Masataka Yokoyama; Haruhiro Toko; Kaoru Tateno; Junji Moriya; Ippei Shimizu; Aika Nojima; Takashi Ito; Yohko Yoshida; Yoshio Kobayashi; Hideki Katagiri; Tohru Minamino; Issei Komuro
Journal:  Arterioscler Thromb Vasc Biol       Date:  2012-05-03       Impact factor: 8.311

4.  Antidepressant-like effects of fenofibrate in mice via the hippocampal brain-derived neurotrophic factor signalling pathway.

Authors:  Bo Jiang; Ying-Jie Wang; Hao Wang; Lu Song; Chao Huang; Qing Zhu; Feng Wu; Wei Zhang
Journal:  Br J Pharmacol       Date:  2016-12-09       Impact factor: 8.739

Review 5.  Brain-derived neurotrophic factor (BDNF) regulates glucose and energy metabolism in diabetic mice.

Authors:  Tsutomu Nakagawa; Michiko Ono-Kishino; Eiji Sugaru; Mitsugu Yamanaka; Mutsuo Taiji; Hiroshi Noguchi
Journal:  Diabetes Metab Res Rev       Date:  2002 May-Jun       Impact factor: 4.876

6.  Muscle BDNF improves synaptic and contractile muscle strength in Kennedy's disease mice in a muscle-type specific manner.

Authors:  Katherine Halievski; Youfen Xu; Yazeed W Haddad; Yu Ping Tang; Shinichiro Yamada; Masahisa Katsuno; Hiroaki Adachi; Gen Sobue; S Marc Breedlove; Cynthia L Jordan
Journal:  J Physiol       Date:  2020-05-29       Impact factor: 5.182

7.  Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice.

Authors:  Ganesh V Halade; Yonggang Ma; Trevi A Ramirez; Jianhua Zhang; Qiuxia Dai; Julie G Hensler; Elizabeth F Lopez; Omid Ghasemi; Yu-Fang Jin; Merry L Lindsey
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-10-18       Impact factor: 4.733

Review 8.  TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders.

Authors:  Vivek K Gupta; Yuyi You; Veer Bala Gupta; Alexander Klistorner; Stuart L Graham
Journal:  Int J Mol Sci       Date:  2013-05-13       Impact factor: 5.923

9.  Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models.

Authors:  Kari Pollock; Heather Dahlenburg; Haley Nelson; Kyle D Fink; Whitney Cary; Kyle Hendrix; Geralyn Annett; Audrey Torrest; Peter Deng; Joshua Gutierrez; Catherine Nacey; Karen Pepper; Stefanos Kalomoiris; Johnathon D Anderson; Jeannine McGee; William Gruenloh; Brian Fury; Gerhard Bauer; Alexandria Duffy; Theresa Tempkin; Vicki Wheelock; Jan A Nolta
Journal:  Mol Ther       Date:  2016-01-14       Impact factor: 11.454

10.  Obese mice exposed to psychosocial stress display cardiac and hippocampal dysfunction associated with local brain-derived neurotrophic factor depletion.

Authors:  Jacopo Agrimi; Cristina Spalletti; Carlotta Baroni; Gizem Keceli; Guangshuo Zhu; Angela Caragnano; Marco Matteucci; Stephen Chelko; Genaro A Ramirez-Correa; Djahida Bedja; Valentina Casieri; Nicole Di Lascio; Arianna Scalco; Antonio Paolo Beltrami; Nazareno Paolocci; Matteo Caleo; Vincenzo Lionetti
Journal:  EBioMedicine       Date:  2019-09-03       Impact factor: 8.143
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  8 in total

1.  Effects of two different exercise paradigms on cardiac function, BDNF-TrkB expression, and myocardial protection in the presence and absence of Western diet.

Authors:  Abdulbaset Maroofi; Ahmadreza Bagheri Rouch; Nasim Naderi; Arsalan Damirchi
Journal:  Int J Cardiol Heart Vasc       Date:  2022-04-04

Review 2.  Do Neurotrophins Connect Neurological Disorders and Heart Diseases?

Authors:  Masashi Fujitani; Yoshinori Otani; Hisao Miyajima
Journal:  Biomolecules       Date:  2021-11-19

3.  H3K9me2 regulation of BDNF expression via G9a partakes in the progression of heart failure.

Authors:  Fang Yan; Ziying Chen; Wei Cui
Journal:  BMC Cardiovasc Disord       Date:  2022-04-19       Impact factor: 2.174

4.  Brain-Derived Neurotrophic Factor Expression in Patients with Acute Pulmonary Embolism Compared to the General Population: Diagnostic and Prognostic Implications.

Authors:  Mihai Ștefan Cristian Haba; Ionuț Tudorancea; Cosmin Teodor Mihai; Viviana Onofrei; Irina Iuliana Costache; Antoniu Octavian Petriș; Laurențiu Șorodoc
Journal:  J Clin Med       Date:  2022-08-23       Impact factor: 4.964

5.  Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis.

Authors:  Patrizia Amadio; Chiara Macchi; Chiara Favero; Marta Zarà; Giulia Solazzo; Laura Dioni; Leonardo Sandrini; Luisella Vigna; Maria Francesca Greco; Massimiliano Buoli; Cesare R Sirtori; Angela Cecilia Pesatori; Alessandro Ieraci; Massimiliano Ruscica; Silvia Stella Barbieri; Valentina Bollati
Journal:  Front Cardiovasc Med       Date:  2022-07-13

6.  Exercise Induced-Cytokines Response in Marathon Runners: Role of ACE I/D and BDKRB2 +9/-9 Polymorphisms.

Authors:  Ana Paula Renno Sierra; Bryan Steve Martínez Galán; Cesar Augustus Zocoler de Sousa; Duane Cardoso de Menezes; Jéssica Laís de Oliveira Branquinho; Raquel Leão Neves; Júlia Galanakis Arata; Clarissa Azevedo Bittencourt; Hermes Vieira Barbeiro; Heraldo Possolo de Souza; João Bosco Pesquero; Maria Fernanda Cury-Boaventura
Journal:  Front Physiol       Date:  2022-09-02       Impact factor: 4.755

7.  Enhanced BDNF Actions Following Acute Hypoxia Facilitate HIF-1α-Dependent Upregulation of Cav3-T-Type Ca2+ Channels in Rat Cardiomyocytes.

Authors:  Masaki Morishima; Takafumi Fujita; Satoshi Osagawa; Hiroshi Kubota; Katsushige Ono
Journal:  Membranes (Basel)       Date:  2021-06-25

Review 8.  Altered protein secretion in Batten disease.

Authors:  Robert J Huber
Journal:  Dis Model Mech       Date:  2021-12-06       Impact factor: 5.758
  8 in total

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