Literature DB >> 33477787

mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration.

Palas K Chanda1, Roman Sukhovershin1, John P Cooke1.   

Abstract

mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target "undruggable" diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration.

Entities:  

Keywords:  RNA therapeutics; cardiovascular ageing; cardiovascular regeneration; cell therapy; iPSCs; inflammatory signaling; nuclear reprogramming; transdifferentiation

Mesh：

Substances：

Year:  2021        PMID： 33477787      PMCID： PMC7832270          DOI： 10.3390/cells10010187

Source DB:  PubMed          Journal:  Cells        ISSN： 2073-4409            Impact factor:   6.600


  86 in total

1.  Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability.

Authors:  Katalin Karikó; Hiromi Muramatsu; Frank A Welsh; János Ludwig; Hiroki Kato; Shizuo Akira; Drew Weissman
Journal:  Mol Ther       Date:  2008-09-16       Impact factor: 11.454

Review 2.  Current RNA-based Therapeutics in Clinical Trials.

Authors:  Ling-Yan Zhou; Zhou Qin; Yang-Hui Zhu; Zhi-Yao He; Ting Xu
Journal:  Curr Gene Ther       Date:  2019       Impact factor: 4.391

3.  eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization.

Authors:  H Matsushita; E Chang; A J Glassford; J P Cooke; C P Chiu; P S Tsao
Journal:  Circ Res       Date:  2001-10-26       Impact factor: 17.367

4.  Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.

Authors:  Masaki Ieda; Ji-Dong Fu; Paul Delgado-Olguin; Vasanth Vedantham; Yohei Hayashi; Benoit G Bruneau; Deepak Srivastava
Journal:  Cell       Date:  2010-08-06       Impact factor: 41.582

5.  Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA.

Authors:  Kai Wang; Ruei-Zeng Lin; Xuechong Hong; Alex H Ng; Chin Nien Lee; Joseph Neumeyer; Gang Wang; Xi Wang; Minglin Ma; William T Pu; George M Church; Juan M Melero-Martin
Journal:  Sci Adv       Date:  2020-07-24       Impact factor: 14.136

6.  Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation.

Authors:  Shu Meng; Gang Zhou; Qilin Gu; Palas K Chanda; Frank Ospino; John P Cooke
Journal:  Circ Res       Date:  2016-09-13       Impact factor: 17.367

7.  Messenger RNA- versus retrovirus-based induced pluripotent stem cell reprogramming strategies: analysis of genomic integrity.

Authors:  Clara Steichen; Eléanor Luce; Jérôme Maluenda; Lucie Tosca; Inmaculada Moreno-Gimeno; Christophe Desterke; Noushin Dianat; Sylvie Goulinet-Mainot; Sarah Awan-Toor; Deborah Burks; Joëlle Marie; Anne Weber; Gérard Tachdjian; Judith Melki; Anne Dubart-Kupperschmitt
Journal:  Stem Cells Transl Med       Date:  2014-04-15       Impact factor: 6.940

8.  Optimal ROS Signaling Is Critical for Nuclear Reprogramming.

Authors:  Gang Zhou; Shu Meng; Yanhui Li; Yohannes T Ghebre; John P Cooke
Journal:  Cell Rep       Date:  2016-04-21       Impact factor: 9.423

9.  Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA.

Authors:  Kathy O Lui; Lior Zangi; Eduardo A Silva; Lei Bu; Makoto Sahara; Ronald A Li; David J Mooney; Kenneth R Chien
Journal:  Cell Res       Date:  2013-09-10       Impact factor: 25.617

10.  Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing.

Authors:  Naidi Sun; Bo Ning; Kenny M Hansson; Anthony C Bruce; Scott A Seaman; Chenchu Zhang; Michaela Rikard; Christopher A DeRosa; Cassandra L Fraser; Maria Wågberg; Regina Fritsche-Danielson; Johannes Wikström; Kenneth R Chien; Anna Lundahl; Mikko Hölttä; Leif G Carlsson; Shayn M Peirce; Song Hu
Journal:  Sci Rep       Date:  2018-11-30       Impact factor: 4.379
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  6 in total

Review 1.  Heart regeneration: 20 years of progress and renewed optimism.

Authors:  Jessica C Garbern; Richard T Lee
Journal:  Dev Cell       Date:  2022-02-28       Impact factor: 12.270

2.  The infinite possibilities of RNA therapeutics.

Authors:  Evelyn C Mollocana-Lara; Ming Ni; Spiros N Agathos; Fernando A Gonzales-Zubiate
Journal:  J Ind Microbiol Biotechnol       Date:  2021-12-23       Impact factor: 4.258

3.  Electrically controlled mRNA delivery using a polypyrrole-graphene oxide hybrid film to promote osteogenic differentiation of human mesenchymal stem cells.

Authors:  Huijung Kim; Kübra Solak; Yoojoong Han; Yeon-Woo Cho; Kyeong-Mo Koo; Chang-Dae Kim; Zhengtang Luo; Hyungbin Son; Hyung-Ryong Kim; Ahmet Mavi; Tae-Hyung Kim
Journal:  Nano Res       Date:  2022-07-23       Impact factor: 10.269

Review 4.  mRNA - A game changer in regenerative medicine, cell-based therapy and reprogramming strategies.

Authors:  Oleksandra Chabanovska; Anne-Marie Galow; Robert David; Heiko Lemcke
Journal:  Adv Drug Deliv Rev       Date:  2021-10-13       Impact factor: 17.873

5.  Deciphering the Code: Stem Cell-Immune Function and Cardiac Regeneration.

Authors:  Gustav Steinhoff
Journal:  Cells       Date:  2021-03-08       Impact factor: 6.600

Review 6.  New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery.

Authors:  Adelina-Gabriela Niculescu; Alexandra Cătălina Bîrcă; Alexandru Mihai Grumezescu
Journal:  Pharmaceutics       Date:  2021-12-01       Impact factor: 6.321
  6 in total

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