Literature DB >> 33477534

Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans.

Alberto Cagigi1, Karin Loré1.   

Abstract

In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans.

Entities:  

Keywords:  SARS-CoV-2; Th1 polarization; antibody response; dendritic cell; mRNA vaccine; protein translation; type I interferon

Year:  2021        PMID： 33477534      PMCID： PMC7831080          DOI： 10.3390/vaccines9010061

Source DB:  PubMed          Journal:  Vaccines (Basel)        ISSN： 2076-393X


  79 in total

Review 1.  Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns.

Authors:  Martin F Bachmann; Gary T Jennings
Journal:  Nat Rev Immunol       Date:  2010-10-15       Impact factor: 53.106

2.  Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability.

Authors:  Katalin Karikó; Hiromi Muramatsu; Frank A Welsh; János Ludwig; Hiroki Kato; Shizuo Akira; Drew Weissman
Journal:  Mol Ther       Date:  2008-09-16       Impact factor: 11.454

3.  Apolipoprotein-mediated pathways of lipid antigen presentation.

Authors:  Peter van den Elzen; Salil Garg; Luis León; Manfred Brigl; Elizabeth A Leadbetter; Jenny E Gumperz; Chris C Dascher; Tan-Yun Cheng; Frank M Sacks; Petr A Illarionov; Gurdyal S Besra; Sally C Kent; D Branch Moody; Michael B Brenner
Journal:  Nature       Date:  2005-10-06       Impact factor: 49.962

Review 4.  Antigen Presentation to B Cells.

Authors:  Balthasar A Heesters; Cees E van der Poel; Abhishek Das; Michael C Carroll
Journal:  Trends Immunol       Date:  2016-10-25       Impact factor: 16.687

5.  Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.

Authors:  Akin Akinc; William Querbes; Soma De; June Qin; Maria Frank-Kamenetsky; K Narayanannair Jayaprakash; Muthusamy Jayaraman; Kallanthottathil G Rajeev; William L Cantley; J Robert Dorkin; James S Butler; Liuliang Qin; Timothy Racie; Andrew Sprague; Eugenio Fava; Anja Zeigerer; Michael J Hope; Marino Zerial; Dinah W Y Sah; Kevin Fitzgerald; Mark A Tracy; Muthiah Manoharan; Victor Koteliansky; Antonin de Fougerolles; Martin A Maier
Journal:  Mol Ther       Date:  2010-05-11       Impact factor: 11.454

6.  Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate.

Authors:  H Sands; L J Gorey-Feret; A J Cocuzza; F W Hobbs; D Chidester; G L Trainor
Journal:  Mol Pharmacol       Date:  1994-05       Impact factor: 4.436

7.  Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes.

Authors:  Norbert Pardi; Steven Tuyishime; Hiromi Muramatsu; Katalin Kariko; Barbara L Mui; Ying K Tam; Thomas D Madden; Michael J Hope; Drew Weissman
Journal:  J Control Release       Date:  2015-08-08       Impact factor: 9.776

8.  Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques.

Authors:  Frank Liang; Gustaf Lindgren; Ang Lin; Elizabeth A Thompson; Sebastian Ols; Josefine Röhss; Shinu John; Kimberly Hassett; Olga Yuzhakov; Kapil Bahl; Luis A Brito; Hugh Salter; Giuseppe Ciaramella; Karin Loré
Journal:  Mol Ther       Date:  2017-08-12       Impact factor: 11.454

9.  Induction of cytomegalovirus-specific T cell responses in healthy volunteers and allogeneic stem cell recipients using vaccination with messenger RNA-transfected dendritic cells.

Authors:  Amaryllis H Van Craenenbroeck; Evelien L J Smits; Sébastien Anguille; Ann Van de Velde; Barbara Stein; Tessa Braeckman; Kirsten Van Camp; Griet Nijs; Margareta Ieven; Herman Goossens; Zwi N Berneman; Viggo F I Van Tendeloo; Gert A Verpooten; Pierre Van Damme; Nathalie Cools
Journal:  Transplantation       Date:  2015-01       Impact factor: 4.939

10.  A thermostable messenger RNA based vaccine against rabies.

Authors:  Lothar Stitz; Annette Vogel; Margit Schnee; Daniel Voss; Susanne Rauch; Thorsten Mutzke; Thomas Ketterer; Thomas Kramps; Benjamin Petsch
Journal:  PLoS Negl Trop Dis       Date:  2017-12-07
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  36 in total

1.  Bipolar I Disorder Exacerbation Following COVID-19 Vaccination.

Authors:  Jeffrey Guina; Sara Barlow; Duren Gutierrez
Journal:  Innov Clin Neurosci       Date:  2022 Jul-Sep

2.  Systematic review of spontaneous reports of myocarditis and pericarditis in transplant recipients and immunocompromised patients following COVID-19 mRNA vaccination.

Authors:  Samantha Lane; Alison Yeomans; Saad Shakir
Journal:  BMJ Open       Date:  2022-07-01       Impact factor: 3.006

Review 3.  Towards the future exploration of mucosal mRNA vaccines against emerging viral diseases; lessons from existing next-generation mucosal vaccine strategies.

Authors:  Sodiq A Hameed; Stephane Paul; Giann Kerwin Y Dellosa; Dolores Jaraquemada; Muhammad Bashir Bello
Journal:  NPJ Vaccines       Date:  2022-06-28       Impact factor: 9.399

Review 4.  mRNA Vaccines: Why Is the Biology of Retroposition Ignored?

Authors:  Tomislav Domazet-Lošo
Journal:  Genes (Basel)       Date:  2022-04-20       Impact factor: 4.141

Review 5.  An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times.

Authors:  Cielo García-Montero; Oscar Fraile-Martínez; Coral Bravo; Diego Torres-Carranza; Lara Sanchez-Trujillo; Ana M Gómez-Lahoz; Luis G Guijarro; Natalio García-Honduvilla; Angel Asúnsolo; Julia Bujan; Jorge Monserrat; Encarnación Serrano; Melchor Álvarez-Mon; Juan A De León-Luis; Miguel A Álvarez-Mon; Miguel A Ortega
Journal:  Vaccines (Basel)       Date:  2021-04-27

Review 6.  Therapeutic vaccination for treatment of chronic hepatitis B.

Authors:  Tamsin Cargill; Eleanor Barnes
Journal:  Clin Exp Immunol       Date:  2021-06-08       Impact factor: 5.732

7.  SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses.

Authors:  Jackson S Turner; Jane A O'Halloran; Elizaveta Kalaidina; Wooseob Kim; Aaron J Schmitz; Julian Q Zhou; Tingting Lei; Mahima Thapa; Rita E Chen; James Brett Case; Fatima Amanat; Adriana M Rauseo; Alem Haile; Xuping Xie; Michael K Klebert; Teresa Suessen; William D Middleton; Pei-Yong Shi; Florian Krammer; Sharlene A Teefey; Michael S Diamond; Rachel M Presti; Ali H Ellebedy
Journal:  Nature       Date:  2021-06-28       Impact factor: 49.962

8.  mRNA Innovates the Vaccine Field.

Authors:  Norbert Pardi
Journal:  Vaccines (Basel)       Date:  2021-05-11

Review 9.  A Comprehensive Review of COVID-19 Virology, Vaccines, Variants, and Therapeutics.

Authors:  Lauren Forchette; William Sebastian; Tuoen Liu
Journal:  Curr Med Sci       Date:  2021-07-09

10.  Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients.

Authors:  Cristina Bergamaschi; Evangelos Terpos; Margherita Rosati; Matthew Angel; Jenifer Bear; Dimitris Stellas; Sevasti Karaliota; Filia Apostolakou; Tina Bagratuni; Dimitris Patseas; Sentiljana Gumeni; Ioannis P Trougakos; Meletios A Dimopoulos; Barbara K Felber; George N Pavlakis
Journal:  Cell Rep       Date:  2021-07-23       Impact factor: 9.423
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