BACKGROUND: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and prognosis of CHF in this setting. METHODS: This single-center study included 829 consecutive patients with SARS-CoV-2 infection from February to April 2020. Patients with a previous history of CHF were matched 1:2 for age and sex. We analyze the prognostic value of pre-existing CHF. Prognostic implications of N terminal pro brain natriuretic peptide (NT-proBNP) levels on admission in the CHF cohort were explored. RESULTS: A total of 129 patients (43 CHF and 86 non-CHF) where finally included. All-cause mortality was higher in CHF patients compared to non-CHF patients (51.2% vs. 29.1%, p = 0.014). CHF was independently associated with 30-day mortality (hazard ratio (HR) 2.3, confidence interval (CI) 95%: 1.26-2.4). Patients with CHF and high-sensitivity troponin T < 14 ng/L showed excellent prognosis. An NT-proBNP level > 2598 pg/mL on admission was associated with higher 30-day mortality in patients with CHF. CONCLUSIONS: All-cause mortality in CHF patients hospitalized due to SARS-CoV-2 infection was 51.2%. CHF was independently associated with all-cause mortality (HR 2.3, CI 95% 1.26-4.2). NT-proBNP levels could be used for stratification risk purposes to guide medical decisions if larger studies confirm this finding.
BACKGROUND: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and prognosis of CHF in this setting. METHODS: This single-center study included 829 consecutive patients with SARS-CoV-2 infection from February to April 2020. Patients with a previous history of CHF were matched 1:2 for age and sex. We analyze the prognostic value of pre-existing CHF. Prognostic implications of N terminal pro brain natriuretic peptide (NT-proBNP) levels on admission in the CHF cohort were explored. RESULTS: A total of 129 patients (43 CHF and 86 non-CHF) where finally included. All-cause mortality was higher in CHF patients compared to non-CHFpatients (51.2% vs. 29.1%, p = 0.014). CHF was independently associated with 30-day mortality (hazard ratio (HR) 2.3, confidence interval (CI) 95%: 1.26-2.4). Patients with CHF and high-sensitivity troponin T < 14 ng/L showed excellent prognosis. An NT-proBNP level > 2598 pg/mL on admission was associated with higher 30-day mortality in patients with CHF. CONCLUSIONS: All-cause mortality in CHF patients hospitalized due to SARS-CoV-2 infection was 51.2%. CHF was independently associated with all-cause mortality (HR 2.3, CI 95% 1.26-4.2). NT-proBNP levels could be used for stratification risk purposes to guide medical decisions if larger studies confirm this finding.
Authors: Jesus Alvarez-Garcia; Samuel Lee; Arjun Gupta; Matthew Cagliostro; Aditya A Joshi; Mercedes Rivas-Lasarte; Johanna Contreras; Sumeet S Mitter; Gina LaRocca; Pilar Tlachi; Danielle Brunjes; Benjamin S Glicksberg; Matthew A Levin; Girish Nadkarni; Zahi Fayad; Valentin Fuster; Donna Mancini; Anuradha Lala Journal: J Am Coll Cardiol Date: 2020-10-28 Impact factor: 24.094
Authors: Juan R Rey; Juan Caro-Codón; Sandra O Rosillo; Ángel M Iniesta; Sergio Castrejón-Castrejón; Irene Marco-Clement; Lorena Martín-Polo; Carlos Merino-Argos; Laura Rodríguez-Sotelo; Jose M García-Veas; Luis A Martínez-Marín; Marcel Martínez-Cossiani; Antonio Buño; Luis Gonzalez-Valle; Alicia Herrero; José L López-Sendón; José L Merino Journal: Eur J Heart Fail Date: 2020-10-07 Impact factor: 17.349
Authors: Marta Herrero-Torrus; Neus Badosa; Cristina Roqueta; Sonia Ruiz-Bustillo; Eduard Solé-González; Laia C Belarte-Tornero; Sandra Valdivielso-Moré; Olga Vázquez; Núria Farré Journal: J Clin Med Date: 2022-03-30 Impact factor: 4.241
Authors: Giuseppe Rosano; Ewa A Jankowska; Robin Ray; Marco Metra; Magdy Abdelhamid; Stamatis Adamopoulos; Stefan D Anker; Antoni Bayes-Genis; Yury Belenkov; Tuvia B Gal; Michael Böhm; Ovidiu Chioncel; Alain Cohen-Solal; Dimitrios Farmakis; Gerasimos Filippatos; Arantxa González; Finn Gustafsson; Loreena Hill; Tiny Jaarsma; Fadi Jouhra; Mitja Lainscak; Ekaterini Lambrinou; Yury Lopatin; Lars H Lund; Davor Milicic; Brenda Moura; Wilfried Mullens; Massimo F Piepoli; Piotr Ponikowski; Amina Rakisheva; Arsen Ristic; Gianluigi Savarese; Petar Seferovic; Michele Senni; Thomas Thum; Carlo G Tocchetti; Sophie Van Linthout; Maurizio Volterrani; Andrew J S Coats Journal: Eur J Heart Fail Date: 2021-11 Impact factor: 15.534
Authors: Laure-Alix Clerbaux; Maria Cristina Albertini; Núria Amigó; Anna Beronius; Gillina F G Bezemer; Sandra Coecke; Evangelos P Daskalopoulos; Giusy Del Giudice; Dario Greco; Lucia Grenga; Alberto Mantovani; Amalia Muñoz; Elma Omeragic; Nikolaos Parissis; Mauro Petrillo; Laura A Saarimäki; Helena Soares; Kristie Sullivan; Brigitte Landesmann Journal: J Clin Med Date: 2022-07-31 Impact factor: 4.964