| Literature DB >> 3347612 |
T Watanabe1, T Kawada, K Iwai.
Abstract
The effect of capsaicin pretreatment on adrenal catecholamine secretion induced by intravenously administered capsaicin was investigated in alpha-chloralose and urethane anesthetized rats. In neonatal vehicle pretreated rats, capsaicin (200 micrograms/kg, iv) caused a rapid and significant increase in adrenal epinephrine secretion, but neonatal capsaicin pretreatment (50 mg/kg, sc, on the 2nd day of life) significantly reduced both the basal and capsaicin-induced epinephrine secretion from the adrenal medulla. Adult capsaicin pretreatment (6 increasing doses/6 days, total 310 mg/kg, sc) also reduced both the basal and capsaicin-stimulated adrenal epinephrine secretion, though it was less effective compared with the neonatal capsaicin pretreatment. These results suggest the participation of capsaicin-sensitive neurons in capsaicin-induced catecholamine secretion from the adrenal medulla.Entities:
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Year: 1988 PMID： 3347612 DOI： 10.3181/00379727-187-3-rc1
Source DB: PubMed Journal: Proc Soc Exp Biol Med ISSN： 0037-9727