| Literature DB >> 33476015 |
Pietro Irrera1, Lorena Consolino2, Walter Dastrù2, Michael Pedersen3, Frank G Zöllner4, Dario Livio Longo5.
Abstract
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can provide a noninvasive way for assessing renal functional information following the administration of a small molecular weight gadolinium-based contrast agent. This method may be useful for investigating renal perfusion and glomerular filtration rates of rodents in vivo under various experimental (patho)physiological conditions. Here we describe a step-by-step protocol for DCE-MRI studies in small animals providing practical notes on acquisition parameters, sequences, T1 mapping approaches and procedures.This chapters is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This experimental protocol chapter is complemented by two separate chapters describing the basic concept and data analysis.Entities:
Keywords: Contrast agent; Dynamic contrast-enhanced (DCE); Kidney; Magnetic resonance imaging (MRI); Mice; Rats; T1 map
Year: 2021 PMID： 33476015 DOI： 10.1007/978-1-0716-0978-1_25
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745