| Literature DB >> 33475996 |
Kathleen Cantow1, Roger G Evans2, Dirk Grosenick3, Thomas Gladytz3, Thoralf Niendorf4, Bert Flemming1, Erdmann Seeliger5.
Abstract
Renal tissue hypoperfusion and hypoxia are early key elements in the pathophysiology of acute kidney injury of various origins, and may also promote progression from acute injury to chronic kidney disease. Here we describe basic principles of methodology to quantify renal hemodynamics and tissue oxygenation by means of invasive probes in experimental animals. Advantages and disadvantages of the various methods are discussed in the context of the heterogeneity of renal tissue perfusion and oxygenation.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by a separate chapter describing the experimental procedure and data analysis.Entities:
Keywords: In vivo methods; Quantitative invasive probes; Renal hemodynamics and oxygenation
Year: 2021 PMID： 33475996 DOI： 10.1007/978-1-0716-0978-1_6
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745