| Literature DB >> 33475162 |
Angelica Rico1, Sheila C Dollard2, Diana Valencia3, Sheryll Corchuelo1, Van T Tong3, Katherine Laiton-Donato1, Minal M Amin2, Monica Benavides4, Phili Wong2, Suzanne Newton5, Marcela Daza4, Jordan Cates3, Maritza Gonzalez1, Laura D Zambrano3, Marcela M Mercado1, Elizabeth C Ailes3, Helena M Rodriguez1, Suzanne M Gilboa3, Jacqueline Acosta4, Jessica Ricaldi3, Dioselina Pelaez1, Margaret A Honein3, Martha L Ospina1, Tatiana M Lanzieri2.
Abstract
We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8-12) weeks gestation (n = 1501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5%-98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9%-18.3%; 6/711) per 1000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%-59.1%) had postnatal infection.Entities:
Keywords: CMV; Colombia; congenital infection; cytomegalovirus; newborns; postnatal infection; prevalence; seroprevalence
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Year: 2021 PMID： 33475162 PMCID： PMC8292416 DOI： 10.1002/jmv.26815
Source DB: PubMed Journal: J Med Virol ISSN： 0146-6615 Impact factor: 20.693