Massimo De Martinis1,2, Maria Maddalena Sirufo1,3, Matteo Polsinelli4, Giuseppe Placidi4, Daniela Di Silvestre1,3, Lia Ginaldi1,3. 1. Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy. 2. Allergy and Clinical Immunology Unit, Center for the Diagnosis and Treatment of Osteoporosis, Teramo, Italy. demartinis@cc.univaq.it. 3. Allergy and Clinical Immunology Unit, Center for the Diagnosis and Treatment of Osteoporosis, Teramo, Italy. 4. A2VI-Lab, Department of Life, Health and Environmental Sciences, L'Aquila, Italy.
Abstract
PURPOSE: Osteoporosis affects more than 200 million people worldwide: its prevalence increases with age and is actually growing due to the constant population aging. Women are at greater risk than men, but in recent years it has become increasingly evident that osteoporosis represents a significantly important problem also for men. However, osteoporosis in men is still poorly studied, underdiagnosed and inadequately treated. MATERIALS AND METHODS: We conducted an observational study to identify any gender disparities in osteoporosis screening. For this purpose we observed people consecutively admitted at our Outpatient Service for the Diagnosis of Osteoporosis during the last 3 years. Patients underwent clinical and laboratory assessment and bone mineral density (BMD) measurements by dual-energy X-ray absorptiometry. Bone turnover serum markers have been evaluated and stratified according to gender. RESULTS: Out of 3,752 patients, 2,376 subjects who met the inclusion criteria were identified. As expected, the great majority (94.5%) of the screened subjects were women and only 5.4% were men. Women exhibited lower BMD compared to men (T-score values: -2.33±1.14 vs. -1.31±1.55; p<0.001), whereas the prevalence of fractures in osteoporotic men was significantly higher (50% vs. 31%; p<0.001). Women had lower vitamin D and higher bone remodeling markers compared to men. Secondary osteoporosis was more frequent in men (66.67%) than in women (20.83%) and the calculated risk for hip fractures was higher in osteoporotic men compared to women (11.47±10.62 vs. 6.87±7.73; p<0.001). CONCLUSIONS: Here we highlighted that men are under-screened for osteoporosis and exhibit secondary osteoporosis more frequently than women.
PURPOSE:Osteoporosis affects more than 200 million people worldwide: its prevalence increases with age and is actually growing due to the constant population aging. Women are at greater risk than men, but in recent years it has become increasingly evident that osteoporosis represents a significantly important problem also for men. However, osteoporosis in men is still poorly studied, underdiagnosed and inadequately treated. MATERIALS AND METHODS: We conducted an observational study to identify any gender disparities in osteoporosis screening. For this purpose we observed people consecutively admitted at our Outpatient Service for the Diagnosis of Osteoporosis during the last 3 years. Patients underwent clinical and laboratory assessment and bone mineral density (BMD) measurements by dual-energy X-ray absorptiometry. Bone turnover serum markers have been evaluated and stratified according to gender. RESULTS: Out of 3,752 patients, 2,376 subjects who met the inclusion criteria were identified. As expected, the great majority (94.5%) of the screened subjects were women and only 5.4% were men. Women exhibited lower BMD compared to men (T-score values: -2.33±1.14 vs. -1.31±1.55; p<0.001), whereas the prevalence of fractures in osteoporoticmen was significantly higher (50% vs. 31%; p<0.001). Women had lower vitamin D and higher bone remodeling markers compared to men. Secondary osteoporosis was more frequent in men (66.67%) than in women (20.83%) and the calculated risk for hip fractures was higher in osteoporoticmen compared to women (11.47±10.62 vs. 6.87±7.73; p<0.001). CONCLUSIONS: Here we highlighted that men are under-screened for osteoporosis and exhibit secondary osteoporosis more frequently than women.
Authors: Jun Kou; Chunyang He; Lin Cui; Zhengping Zhang; Wei Wang; Li Tan; Da Liu; Wei Zheng; Wei Gu; Ning Xia Journal: Front Endocrinol (Lausanne) Date: 2022-04-19 Impact factor: 6.055
Authors: Maria Maddalena Sirufo; Francesca De Pietro; Alessandra Catalogna; Lia Ginaldi; Massimo De Martinis Journal: Int J Environ Res Public Health Date: 2021-12-28 Impact factor: 3.390
Authors: Małgorzata Dziedzic; Mariola Janiszewska; Małgorzata Goździewska; Wioleta Kowalska; Jacek Roliński Journal: Int J Environ Res Public Health Date: 2022-09-27 Impact factor: 4.614