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Literature DB >> 33472954

Does protein aggregation drive postmitotic tissue degeneration?

Abstract

Pharmacological evidence, from clinical trials where patients with systemic amyloid diseases are treated with disease-modifying therapies, supports the notion that protein aggregation drives tissue degeneration in these disorders. The protein aggregate structures driving tissue pathology and the commonalities in etiology between these diseases and Alzheimer's disease are under investigation.

Entities: Chemical

Mesh：

Substances：

Year: 2021 PMID： 33472954 PMCID： PMC9447413 DOI： 10.1126/scitranslmed.aax0914

Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 19.319

42 in total

1. Influence of a Single Point Mutation in the Constant Domain of the Bence-Jones Protein bif on Its Aggregation Properties.

Authors: M A Timchenko; A A Timchenko
Journal: Biochemistry (Mosc) Date: 2018-02 Impact factor: 2.487

2. Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart.

Authors: Luca Troncone; Marco Luciani; Matthew Coggins; Elissa H Wilker; Cheng-Ying Ho; Kari Elise Codispoti; Matthew P Frosch; Rakez Kayed; Federica Del Monte
Journal: J Am Coll Cardiol Date: 2016-12-06 Impact factor: 24.094

3. Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis.

Authors: David Adams; Alejandra Gonzalez-Duarte; William D O'Riordan; Chih-Chao Yang; Mitsuharu Ueda; Arnt V Kristen; Ivailo Tournev; Hartmut H Schmidt; Teresa Coelho; John L Berk; Kon-Ping Lin; Giuseppe Vita; Shahram Attarian; Violaine Planté-Bordeneuve; Michelle M Mezei; Josep M Campistol; Juan Buades; Thomas H Brannagan; Byoung J Kim; Jeeyoung Oh; Yesim Parman; Yoshiki Sekijima; Philip N Hawkins; Scott D Solomon; Michael Polydefkis; Peter J Dyck; Pritesh J Gandhi; Sunita Goyal; Jihong Chen; Andrew L Strahs; Saraswathy V Nochur; Marianne T Sweetser; Pushkal P Garg; Akshay K Vaishnaw; Jared A Gollob; Ole B Suhr
Journal: N Engl J Med Date: 2018-07-05 Impact factor: 91.245

4. Predictive model of response to tafamidis in hereditary ATTR polyneuropathy.

Authors: Cecília Monteiro; Jaleh S Mesgazardeh; João Anselmo; Joana Fernandes; Marta Novais; Carla Rodrigues; Gabriel J Brighty; David L Powers; Evan T Powers; Teresa Coelho; Jeffery W Kelly
Journal: JCI Insight Date: 2019-06-20

5. Incidence of serious upper and lower gastrointestinal events in older adults with and without Alzheimer's disease.

Authors: Jasmanda H Wu; Zhenchao Guo; Sandeep Kumar; Pablo Lapuerta
Journal: J Am Geriatr Soc Date: 2011-10-21 Impact factor: 5.562

6. Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.

Authors: Joseph D Schonhoft; Cecilia Monteiro; Lars Plate; Yvonne S Eisele; John M Kelly; Daniel Boland; Christopher G Parker; Benjamin F Cravatt; Sergio Teruya; Stephen Helmke; Mathew Maurer; John Berk; Yoshiki Sekijima; Marta Novais; Teresa Coelho; Evan T Powers; Jeffery W Kelly
Journal: Sci Transl Med Date: 2017-09-13 Impact factor: 17.956

7. Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial.

Authors: John L Berk; Ole B Suhr; Laura Obici; Yoshiki Sekijima; Steven R Zeldenrust; Taro Yamashita; Michael A Heneghan; Peter D Gorevic; William J Litchy; Janice F Wiesman; Erik Nordh; Manuel Corato; Alessandro Lozza; Andrea Cortese; Jessica Robinson-Papp; Theodore Colton; Denis V Rybin; Alice B Bisbee; Yukio Ando; Shu-ichi Ikeda; David C Seldin; Giampaolo Merlini; Martha Skinner; Jeffery W Kelly; Peter J Dyck
Journal: JAMA Date: 2013-12-25 Impact factor: 56.272

Review 8. The amyloid state of proteins in human diseases.

Authors: David Eisenberg; Mathias Jucker
Journal: Cell Date: 2012-03-16 Impact factor: 41.582

9. Altered diastolic function and aortic stiffness in Alzheimer's disease.

Authors: Ali Nazmi Çalık; Kazım Serhan Özcan; Gülbün Yüksel; Barısş Güngör; Emre Aruğarslan; Figen Varlibas; Ahmet Ekmekci; Damirbek Osmonov; Mustafa Adem Tatlısu; Mehmet Karaca; Osman Bolca; İzzet Erdinler
Journal: Clin Interv Aging Date: 2014-07-16 Impact factor: 4.458

10. Cryo-EM structures of tau filaments from Alzheimer's disease.

Authors: Anthony W P Fitzpatrick; Benjamin Falcon; Shaoda He; Alexey G Murzin; Garib Murshudov; Holly J Garringer; R Anthony Crowther; Bernardino Ghetti; Michel Goedert; Sjors H W Scheres
Journal: Nature Date: 2017-07-05 Impact factor: 49.962

5 in total

1. A circulating, disease-specific, mechanism-linked biomarker for ATTR polyneuropathy diagnosis and response to therapy prediction.

Authors: Xin Jiang; Richard Labaudinière; Joel N Buxbaum; Cecília Monteiro; Marta Novais; Teresa Coelho; Jeffery W Kelly
Journal: Proc Natl Acad Sci U S A Date: 2021-03-02 Impact factor: 11.205

Review 2. Molecular mechanisms of amyloid formation in living systems.

Authors: Tessa Sinnige
Journal: Chem Sci Date: 2022-05-17 Impact factor: 9.969

3. Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.

Authors: Nicholas L Yan; Diogo Santos-Martins; Reji Nair; Alan Chu; Ian A Wilson; Kristen A Johnson; Stefano Forli; Gareth J Morgan; H Michael Petrassi; Jeffery W Kelly
Journal: J Med Chem Date: 2021-05-03 Impact factor: 7.446

Review 4. (Dis)Solving the problem of aberrant protein states.

Authors: Charlotte M Fare; James Shorter
Journal: Dis Model Mech Date: 2021-05-04 Impact factor: 5.758

5. Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site.

Authors: Nicholas L Yan; Reji Nair; Alan Chu; Ian A Wilson; Kristen A Johnson; Gareth J Morgan; Jeffery W Kelly
Journal: Bioorg Med Chem Lett Date: 2022-01-19 Impact factor: 2.823

5 in total