Literature DB >> 33472820

Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease.

Lyandysha V Zholudeva1, Victoria E Abraira2, Kajana Satkunendrarajah3,4, Todd C McDevitt5,6, Martyn D Goulding7, David S K Magnuson8, Michael A Lane9.   

Abstract

Spinal interneurons are important facilitators and modulators of motor, sensory, and autonomic functions in the intact CNS. This heterogeneous population of neurons is now widely appreciated to be a key component of plasticity and recovery. This review highlights our current understanding of spinal interneuron heterogeneity, their contribution to control and modulation of motor and sensory functions, and how this role might change after traumatic spinal cord injury. We also offer a perspective for how treatments can optimize the contribution of interneurons to functional improvement.
Copyright © 2021 the authors.

Entities:  

Keywords:  interneuron; plasticity; propriospinal; spinal cord

Mesh：

Substances：

Year:  2021        PMID： 33472820      PMCID： PMC7880285          DOI： 10.1523/JNEUROSCI.1654-20.2020

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.709


  143 in total

1.  Mapping Sub-Second Structure in Mouse Behavior.

Authors:  Alexander B Wiltschko; Matthew J Johnson; Giuliano Iurilli; Ralph E Peterson; Jesse M Katon; Stan L Pashkovski; Victoria E Abraira; Ryan P Adams; Sandeep Robert Datta
Journal:  Neuron       Date:  2015-12-16       Impact factor: 17.173

Review 2.  Locomotor circuits in the mammalian spinal cord.

Authors:  Ole Kiehn
Journal:  Annu Rev Neurosci       Date:  2006       Impact factor: 12.449

3.  Analysis of forelimb-hindlimb reflex activity in acutely decapitate cats.

Authors:  D P C LLOYD; A K MciNTYRE
Journal:  J Neurophysiol       Date:  1948-09       Impact factor: 2.714

4.  Firing and cellular properties of V2a interneurons in the rodent spinal cord.

Authors:  Kimberly J Dougherty; Ole Kiehn
Journal:  J Neurosci       Date:  2010-01-06       Impact factor: 6.167

5.  Processing information related to centrally initiated locomotor and voluntary movements by feline spinocerebellar neurones.

Authors:  E Jankowska; E Nilsson; I Hammar
Journal:  J Physiol       Date:  2011-09-19       Impact factor: 5.182

6.  Extensive respiratory plasticity after cervical spinal cord injury in rats: axonal sprouting and rerouting of ventrolateral bulbospinal pathways.

Authors:  Fannie Darlot; Florence Cayetanot; Patrick Gauthier; Valéry Matarazzo; Anne Kastner
Journal:  Exp Neurol       Date:  2012-04-19       Impact factor: 5.330

7.  Lasting paraplegia caused by loss of lumbar spinal cord interneurons in rats: no direct correlation with motor neuron loss.

Authors:  B Hadi; Y P Zhang; D A Burke; C B Shields; D S Magnuson
Journal:  J Neurosurg       Date:  2000-10       Impact factor: 5.115

8.  Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury.

Authors:  Gregoire Courtine; Bingbing Song; Roland R Roy; Hui Zhong; Julia E Herrmann; Yan Ao; Jingwei Qi; V Reggie Edgerton; Michael V Sofroniew
Journal:  Nat Med       Date:  2008-01-06       Impact factor: 53.440

Review 9.  Molecular and cellular development of spinal cord locomotor circuitry.

Authors:  Daniel C Lu; Tianyi Niu; William A Alaynick
Journal:  Front Mol Neurosci       Date:  2015-06-16       Impact factor: 5.639

10.  Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts.

Authors:  Jennifer N Dulin; Andrew F Adler; Hiromi Kumamaru; Gunnar H D Poplawski; Corinne Lee-Kubli; Hans Strobl; Daniel Gibbs; Ken Kadoya; James W Fawcett; Paul Lu; Mark H Tuszynski
Journal:  Nat Commun       Date:  2018-01-08       Impact factor: 14.919
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  9 in total

1.  Brain-wide analysis of the supraspinal connectome reveals anatomical correlates to functional recovery after spinal injury.

Authors:  Zimei Wang; Adam Romanski; Vatsal Mehra; Yunfang Wang; Matthew Brannigan; Benjamin C Campbell; Gregory A Petsko; Pantelis Tsoulfas; Murray G Blackmore
Journal:  Elife       Date:  2022-07-15       Impact factor: 8.713

2.  Thoracic VGluT2+ Spinal Interneurons Regulate Structural and Functional Plasticity of Sympathetic Networks after High-Level Spinal Cord Injury.

Authors:  Benjamin T Noble; Faith H Brennan; Yan Wang; Zhen Guan; Xiaokui Mo; Jan M Schwab; Phillip G Popovich
Journal:  J Neurosci       Date:  2022-03-18       Impact factor: 6.709

Review 3.  Transneuronal tracing to map connectivity in injured and transplanted spinal networks.

Authors:  Tara A Fortino; Margo L Randelman; Adam A Hall; Jasbir Singh; David C Bloom; Esteban Engel; Daniel J Hoh; Shaoping Hou; Lyandysha V Zholudeva; Michael A Lane
Journal:  Exp Neurol       Date:  2022-01-25       Impact factor: 5.620

Review 4.  Respiratory Training and Plasticity After Cervical Spinal Cord Injury.

Authors:  Margo Randelman; Lyandysha V Zholudeva; Stéphane Vinit; Michael A Lane
Journal:  Front Cell Neurosci       Date:  2021-09-21       Impact factor: 6.147

5.  Selective Loss of MATR3 in Spinal Interneurons, Upper Motor Neurons and Hippocampal CA1 Neurons in a MATR3 S85C Knock-In Mouse Model of Amyotrophic Lateral Sclerosis.

Authors:  Justin You; Katarina Maksimovic; Jooyun Lee; Mashiat Khan; Rintaro Masuda; Jeehye Park
Journal:  Biology (Basel)       Date:  2022-02-12

6.  Diversified physiological sensory input connectivity questions the existence of distinct classes of spinal interneurons.

Authors:  Matthias Kohler; Fredrik Bengtsson; Philipp Stratmann; Florian Röhrbein; Alois Knoll; Alin Albu-Schäffer; Henrik Jörntell
Journal:  iScience       Date:  2022-03-17

7.  Spinal dI4 Interneuron Differentiation From Human Pluripotent Stem Cells.

Authors:  Jia Xu; Liang-Jiang Huang; Zhengyu Fang; Hong-Mei Luo; Yun-Qiang Chen; Ya-Jie Li; Chen-Zi Gong; Hong Chen
Journal:  Front Mol Neurosci       Date:  2022-04-08       Impact factor: 5.639

8.  Chemogenetic modulation of sensory afferents induces locomotor changes and plasticity after spinal cord injury.

Authors:  Jaclyn T Eisdorfer; Hannah Sobotka-Briner; Susan Schramfield; George Moukarzel; Jie Chen; Thomas J Campion; Rupert Smit; Bradley C Rauscher; Michel A Lemay; George M Smith; Andrew J Spence
Journal:  Front Mol Neurosci       Date:  2022-08-26       Impact factor: 6.261

9.  Unusual Quadrupedal Locomotion in Rat during Recovery from Lumbar Spinal Blockade of 5-HT7 Receptors.

Authors:  Urszula Sławińska; Henryk Majczyński; Anna Kwaśniewska; Krzysztof Miazga; Anna M Cabaj; Marek Bekisz; Larry M Jordan; Małgorzata Zawadzka
Journal:  Int J Mol Sci       Date:  2021-06-02       Impact factor: 5.923
  9 in total

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