Antonio Preti1,2, Roberto Demontis3, Giulia Cossu3, Goce Kalcev4, Federico Cabras3, Maria Francesca Moro5, Ferdinando Romano6, Matteo Balestrieri7, Filippo Caraci8,9, Liliana Dell'Osso10, Guido Di Sciascio11, Filippo Drago8, Maria Carolina Hardoy12, Rita Roncone13, Carlo Faravelli14, Cesar Ivan Aviles Gonzalez3,15, Matthias Angermayer16, Mauro Giovanni Carta3. 1. University of Cagliari, Cagliari, Italy. apreti@tin.it. 2. Department of Neuroscience "Rita Levi Montalcini", University of Turin, via Cherasco 15, 10126, Turin, Italy. apreti@tin.it. 3. University of Cagliari, Cagliari, Italy. 4. Department of Innovation Sciences and Technologies, University of Cagliari, Cagliari, Italy. 5. Mailman School of Public Health, Columbia University, New York, USA. 6. University of Roma La Sapienza, Rome, Italy. 7. University of Udine, Udine, Italy. 8. Department of Drug Sciences, University of Catania, Catania, Italy. 9. Oasi Research Institute-IRCCS, Troina, Italy. 10. University of Pisa, Pisa, Italy. 11. University of Bari, Bari, Italy. 12. Azienda Ospedaliera Brotzu, Cagliari, Italy. 13. University of L'Aquila, L'Aquila, Italy. 14. University of Florence, Florence, Italy. 15. Universidad Popular del Cesar, Valledupar, Cesar, Colombia. 16. Center for Public Mental Health, Gosim, Austria.
Abstract
BACKGROUND: Generalized anxiety disorder (GAD) is one of the most reported diagnoses in psychiatry, but there is some discrepancy between the cases identified in community studies and those identified in tertiary care. This study set out to evaluate whether the use of clinicians as interviewers may provide estimates in a community survey close to those observed in primary or specialized care. METHODS: This is a community survey on a randomly selected sample of 2338 adult subjects. The Advanced Neuropsychiatric Tools and Assessment Schedule (ANTAS) was administered by clinicians, providing lifetime diagnosis based on the DSM-IV-TR. Health-related quality of life (HR-QoL) was measured with the Short-Form Health Survey (SF-12). RESULTS: Overall, 55 (2.3%) subjects met the criteria for GAD, with greater prevalence in women (3.6%) than in men (0.9%): OR = 4.02; 95%CI: 1.96-8.26. Up to 40% of those with GAD had at least another diagnosis of mood, anxiety, or eating disorders. The mean score of SF-12 in people with GAD was 32.33 ± 6.8, with a higher attributable burden than in other conditions except for major depressive disorder. CONCLUSIONS: We found a relatively lower lifetime prevalence of GAD than in community surveys based on lay interviewers and a structured interview. The identified cases of GAD showed a strong impact on the quality of life regardless of co-morbidity and high risk in women, suggesting a profile similar to the one identified from studies in primary and specialized care.
BACKGROUND:Generalized anxiety disorder (GAD) is one of the most reported diagnoses in psychiatry, but there is some discrepancy between the cases identified in community studies and those identified in tertiary care. This study set out to evaluate whether the use of clinicians as interviewers may provide estimates in a community survey close to those observed in primary or specialized care. METHODS: This is a community survey on a randomly selected sample of 2338 adult subjects. The Advanced Neuropsychiatric Tools and Assessment Schedule (ANTAS) was administered by clinicians, providing lifetime diagnosis based on the DSM-IV-TR. Health-related quality of life (HR-QoL) was measured with the Short-Form Health Survey (SF-12). RESULTS: Overall, 55 (2.3%) subjects met the criteria for GAD, with greater prevalence in women (3.6%) than in men (0.9%): OR = 4.02; 95%CI: 1.96-8.26. Up to 40% of those with GAD had at least another diagnosis of mood, anxiety, or eating disorders. The mean score of SF-12 in people with GAD was 32.33 ± 6.8, with a higher attributable burden than in other conditions except for major depressive disorder. CONCLUSIONS: We found a relatively lower lifetime prevalence of GAD than in community surveys based on lay interviewers and a structured interview. The identified cases of GAD showed a strong impact on the quality of life regardless of co-morbidity and high risk in women, suggesting a profile similar to the one identified from studies in primary and specialized care.
Entities:
Keywords:
Community survey; Comorbidity; Epidemiology; Generalized anxiety disorder; Quality of life
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