| Literature DB >> 33472175 |
Liyu Wang1, Yu Liu1, Hengchang Liu2, He Tian1, Yalong Wang1, Guochao Zhang1, Yuanyuan Lei1, Liyan Xue3, Bo Zheng3, Tao Fan1, Yujia Zheng1, Fengwei Tan1, Qi Xue1, Shugeng Gao1, Chunxiang Li1, Jie He1.
Abstract
Combination therapies based on photodynamic therapy (PDT) have received much attention in various cancers due to their strong therapeutic effects. Here, we aimed to explore the safety and effectiveness of a new mitochondria-targeting photodynamic material, TPE-IQ-2O, in combination therapies (combined with surgery or immunotherapy). The safety and effectiveness of TPE-IQ-2O PDT were verified with cytotoxicity evaluation in vitro and a zebrafish xenograft model in vivo, respectively. The effectiveness of TPE-IQ-2O PDT combined with surgery or immune checkpoint inhibitors (ICIs) was verified in tumor-bearing mice. Small animal in vivo imaging, immunohistochemistry, and flow cytometry were used to determine the underlying mechanism. TPE-IQ-2O PDT can not only reduce tumor recurrence in surgical treatment but also effectively improve the response to ICIs in immunotherapy without obvious toxicity. It was also found to ameliorate the immunosuppressive tumor microenvironment and promote the antitumor immunity induced by ICIs by increasing CD8+ tumor-infiltrating lymphocyte accumulation. Thus, TPE-IQ-2O PDT is a safe and effective antitumor therapy that can be combined with surgery or immunotherapy.Entities:
Keywords: combination therapy; immunotherapy; photodynamic therapy; surgery; tumor microenvironment
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Year: 2020 PMID： 33472175 PMCID： PMC7835032 DOI： 10.18632/aging.202355
Source DB: PubMed Journal: Aging (Albany NY) ISSN： 1945-4589 Impact factor: 5.682