Ithamar Ganmore1, Isak Elkayam2, Ramit Ravona-Springer3, Hung-Mo Lin4, Xiaoyu Liu4, Meir Plotnik5, Aron S Buchman6, Yuval Berman1, Jonathan Schwartz1, Mary Sano7, Anthony Heymann8, Michal Schnaider Beeri9. 1. From the Joseph Sagol Neuroscience Center, Sheba Medical Center, Israel. 2. the Sackler Faculty of Medicine, Tel Aviv University, Israel. 3. From the Joseph Sagol Neuroscience Center, Sheba Medical Center, Israel; the Sackler Faculty of Medicine, Tel Aviv University, Israel. 4. the Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York. 5. the Center for Advanced Technologies in Rehabilitation, Sheba Medical Center, Israel. 6. the Rush Alzheimer's Disease Center, Rush University, Illinois. 7. the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York. 8. the Sackler Faculty of Medicine, Tel Aviv University, Israel; the Maccabi Health Services, Israel. 9. From the Joseph Sagol Neuroscience Center, Sheba Medical Center, Israel; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York. Electronic address: michal.beeri@mssm.edu.
Abstract
OBJECTIVE: Type 2 diabetes (T2D) is associated with motor impairments and a higher dementia risk. The relationships of motor decline with cognitive decline in T2D older adults has rarely been studied. Using data from the Israel Diabetes and Cognitive Decline study (N = 892), we examined associations of decline in motor function with cognitive decline over a 54-month period. METHODS: Motor function measures were strength (handgrip) and gait speed (time to walk 3 m). Participants completed a neuropsychologic battery of 13 tests transformed into z-scores, summarized into 4 cognitive domains: episodic memory, attention/working memory, executive functions, and language/semantic categorization. The average of the 4 domains' z-scores defined global cognition. Motor and cognitive functions were assessed in 18-months intervals. A random coefficients model delineated longitudinal relationships of cognitive decline with baseline and change from baseline in motor function, adjusting for sociodemographic, cardiovascular, and T2D-related covariates. RESULTS: Slower baseline gait speed levels were significantly associated with more rapid decline in global cognition (P = .004), language/semantic categorization (P = .006) and episodic memory (P = .029). Greater decline over time in gait speed was associated with an accelerated rate of decline in global cognition (P = .050), attention/working memory (P = .047) and language/semantic categorization (P<.001). Baseline strength levels were not associated with cognitive decline but the rate of declining strength was associated with an accelerated decline in executive functions (P = .025) and language/semantic categorization (P = .006). CONCLUSION: In T2D older adults, the rate of decline in motor function, beyond baseline levels, was associated with accelerated cognitive decline, suggesting that cognitive and motor decline share common neuropathologic mechanisms in T2D.
OBJECTIVE:Type 2 diabetes (T2D) is associated with motor impairments and a higher dementia risk. The relationships of motor decline with cognitive decline in T2D older adults has rarely been studied. Using data from the Israel Diabetes and Cognitive Decline study (N = 892), we examined associations of decline in motor function with cognitive decline over a 54-month period. METHODS: Motor function measures were strength (handgrip) and gait speed (time to walk 3 m). Participants completed a neuropsychologic battery of 13 tests transformed into z-scores, summarized into 4 cognitive domains: episodic memory, attention/working memory, executive functions, and language/semantic categorization. The average of the 4 domains' z-scores defined global cognition. Motor and cognitive functions were assessed in 18-months intervals. A random coefficients model delineated longitudinal relationships of cognitive decline with baseline and change from baseline in motor function, adjusting for sociodemographic, cardiovascular, and T2D-related covariates. RESULTS: Slower baseline gait speed levels were significantly associated with more rapid decline in global cognition (P = .004), language/semantic categorization (P = .006) and episodic memory (P = .029). Greater decline over time in gait speed was associated with an accelerated rate of decline in global cognition (P = .050), attention/working memory (P = .047) and language/semantic categorization (P<.001). Baseline strength levels were not associated with cognitive decline but the rate of declining strength was associated with an accelerated decline in executive functions (P = .025) and language/semantic categorization (P = .006). CONCLUSION: In T2D older adults, the rate of decline in motor function, beyond baseline levels, was associated with accelerated cognitive decline, suggesting that cognitive and motor decline share common neuropathologic mechanisms in T2D.
Authors: Michal S Beeri; Sue E Leugrans; Osvaldo Delbono; David A Bennett; Aron S Buchman Journal: J Am Geriatr Soc Date: 2021-05-05 Impact factor: 7.538
Authors: Michal Schnaider Beeri; Sue E Leurgans; David A Bennett; Lisa L Barnes; Aron S Buchman Journal: Front Aging Neurosci Date: 2021-09-30 Impact factor: 5.702