Literature DB >> 33471372

Extreme Exposure to Filtered Far-UVC: A Case Study.

Ewan Eadie1, Isla M R Barnard2, Sally H Ibbotson3, Kenneth Wood2.   

Abstract

Far-UVC devices are being commercially sold as "safe for humans" for the inactivation of SARS-CoV-2, without supporting human safety data. We felt there was a need for rapid proof-of-concept human self-exposure, to inform future controlled research and promote informed discussion. A Fitzpatrick Skin Type II individual exposed their inner forearms to large radiant exposures from a filtered Krypton-Chloride (KrCl) far-UVC system (SafeZoneUVC, Ushio Inc., Tokyo, Japan) with peak emission at 222 nm. No visible skin changes were observed at 1500 mJ cm-2 ; whereas, skin yellowing that appeared immediately and resolved within 24 h occurred with a 6000 mJ cm-2 exposure. No erythema was observed at any time point with exposures up to 18 000 mJ cm-2 . These results combined with Monte Carlo Radiative Transfer computer modeling suggest that filtering longer ultraviolet wavelengths is critical for the human skin safety of far-UVC devices. This work also contributes to growing arguments for the exploration of exposure limit expansion, which would subsequently enable faster inactivation of viruses.
© 2021 The Authors. Photochemistry and Photobiology published by Wiley Periodicals LLC on behalf of American Society for Photobiology.

Entities:  

Year:  2021        PMID: 33471372     DOI: 10.1111/php.13385

Source DB:  PubMed          Journal:  Photochem Photobiol        ISSN: 0031-8655            Impact factor:   3.421


  6 in total

1.  Investigation on Potential ESKAPE Surrogates for 222 and 254 nm Irradiation Experiments.

Authors:  Anna-Maria Gierke; Martin Hessling
Journal:  Front Microbiol       Date:  2022-07-01       Impact factor: 6.064

2.  Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation.

Authors:  David Welch; Manuela Buonanno; Andrew G Buchan; Liang Yang; Kirk D Atkinson; Igor Shuryak; David J Brenner
Journal:  Viruses       Date:  2022-03-25       Impact factor: 5.818

Review 3.  The impact of far-UVC radiation (200-230 nm) on pathogens, cells, skin, and eyes - a collection and analysis of a hundred years of data.

Authors:  Martin Hessling; Robin Haag; Nicole Sieber; Petra Vatter
Journal:  GMS Hyg Infect Control       Date:  2021-02-16

Review 4.  Germicidal UV Sources and Systems.

Authors:  Rolf S Bergman
Journal:  Photochem Photobiol       Date:  2021-02-17       Impact factor: 3.521

5.  Far-UVC (222 nm) efficiently inactivates an airborne pathogen in a room-sized chamber.

Authors:  Ewan Eadie; Waseem Hiwar; Louise Fletcher; Emma Tidswell; Paul O'Mahoney; Manuela Buonanno; David Welch; Catherine S Adamson; David J Brenner; Catherine Noakes; Kenneth Wood
Journal:  Sci Rep       Date:  2022-03-23       Impact factor: 4.379

6.  Wavelength-dependent DNA Photodamage in a 3-D human Skin Model over the Far-UVC and Germicidal UVC Wavelength Ranges from 215 to 255 nm.

Authors:  David Welch; Marilena Aquino de Muro; Manuela Buonanno; David J Brenner
Journal:  Photochem Photobiol       Date:  2022-02-18       Impact factor: 3.521

  6 in total

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