Literature DB >> 33470843

Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies.

John C Flickinger1, Jeffrey A Rappaport1, Joshua R Barton1, Trevor R Baybutt1, Amanda M Pattison1, Adam E Snook1, Scott A Waldman1.   

Abstract

Gastrointestinal cancers encompass a diverse class of tumors arising in the GI tract, including esophagus, stomach, pancreas and colorectum. Collectively, gastrointestinal cancers compose a high fraction of all cancer deaths, highlighting an unmet need for novel and effective therapies. In this context, the transmembrane receptor guanylyl cyclase C (GUCY2C) has emerged as an attractive target for the prevention, detection and treatment of many gastrointestinal tumors. GUCY2C is an intestinally-restricted protein implicated in tumorigenesis that is universally expressed by primary and metastatic colorectal tumors as well as ectopically expressed by esophageal, gastric and pancreatic cancers. This review summarizes the current state of GUCY2C-targeted modalities in the management of gastrointestinal malignancies, with special focus on colorectal cancer, the most incident gastrointestinal malignancy.

Entities:  

Keywords:  GUCY2C; biomarker; colorectal cancer; gastrointestinal cancer; immunotherapy

Mesh：

Substances：

Year:  2021        PMID： 33470843      PMCID： PMC8293028          DOI： 10.2217/bmm-2020-0359

Source DB:  PubMed          Journal:  Biomark Med        ISSN： 1752-0363            Impact factor:   2.851


  153 in total

1.  Expression of guanylin is downregulated in mouse and human intestinal adenomas.

Authors:  K A Steinbrecher; T M Tuohy; K Heppner Goss; M C Scott; D P Witte; J Groden; M B Cohen
Journal:  Biochem Biophys Res Commun       Date:  2000-06-24       Impact factor: 3.575

2.  Use of Phosphodiesterase 5 Inhibitors Is Associated With Lower Risk of Colorectal Cancer in Men With Benign Colorectal Neoplasms.

Authors:  Wuqing Huang; Jan Sundquist; Kristina Sundquist; Jianguang Ji
Journal:  Gastroenterology       Date:  2019-05-16       Impact factor: 22.682

3.  Analytical performance of a qRT-PCR assay to detect guanylyl cyclase C in FFPE lymph nodes of patients with colon cancer.

Authors:  Martin Beaulieu; Marie Desaulniers; Nicolas Bertrand; Réna G Deschesnes; Guillaume Beaudry; Geneviève Garon; Jean-François Haince; Michel Houde; Timothy J Holzer
Journal:  Diagn Mol Pathol       Date:  2010-03

4.  Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer.

Authors:  Scott A Waldman; Terry Hyslop; Stephanie Schulz; Alan Barkun; Karl Nielsen; Janis Haaf; Christine Bonaccorso; Yanyan Li; David S Weinberg
Journal:  JAMA       Date:  2009-02-18       Impact factor: 56.272

5.  Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.

Authors:  Shannon L Maude; Theodore W Laetsch; Jochen Buechner; Susana Rives; Michael Boyer; Henrique Bittencourt; Peter Bader; Michael R Verneris; Heather E Stefanski; Gary D Myers; Muna Qayed; Barbara De Moerloose; Hidefumi Hiramatsu; Krysta Schlis; Kara L Davis; Paul L Martin; Eneida R Nemecek; Gregory A Yanik; Christina Peters; Andre Baruchel; Nicolas Boissel; Francoise Mechinaud; Adriana Balduzzi; Joerg Krueger; Carl H June; Bruce L Levine; Patricia Wood; Tetiana Taran; Mimi Leung; Karen T Mueller; Yiyun Zhang; Kapildeb Sen; David Lebwohl; Michael A Pulsipher; Stephan A Grupp
Journal:  N Engl J Med       Date:  2018-02-01       Impact factor: 91.245

6.  Escherichia coli heat-stable toxin receptors in human colonic tumors.

Authors:  S L Carrithers; S J Parkinson; S Goldstein; P Park; D C Robertson; S A Waldman
Journal:  Gastroenterology       Date:  1994-12       Impact factor: 22.682

7.  Escherichia coli Heat-Stable Enterotoxin Mediates Na+/H+ Exchanger 4 Inhibition Involving cAMP in T84 Human Intestinal Epithelial Cells.

Authors:  Ana R Beltrán; Luciene R Carraro-Lacroix; Camila N A Bezerra; Marcelo Cornejo; Katrina Norambuena; Fernando Toledo; Joaquín Araos; Fabián Pardo; Andrea Leiva; Carlos Sanhueza; Gerhard Malnic; Luis Sobrevia; Marco A Ramírez
Journal:  PLoS One       Date:  2015-12-29       Impact factor: 3.240

8.  Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C.

Authors:  Thomas Müller; Insha Rasool; Peter Heinz-Erian; Eva Mildenberger; Christian Hülstrunk; Andreas Müller; Laurent Michaud; Bart G P Koot; Antje Ballauff; Julia Vodopiutz; Stefan Rosipal; Britt-Sabina Petersen; Andre Franke; Irene Fuchs; Heiko Witt; Heinz Zoller; Andreas R Janecke; Sandhya S Visweswariah
Journal:  Gut       Date:  2015-05-20       Impact factor: 23.059

9.  Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors.

Authors:  Marcel J C Bijvelds; Gary Tresadern; Ann Hellemans; Karine Smans; Natascha D A Nieuwenhuijze; Kelly F Meijsen; Jean-Pierre Bongartz; Luc Ver Donck; Hugo R de Jonge; Jan A J Schuurkes; Joris H De Maeyer
Journal:  J Biol Chem       Date:  2018-04-13       Impact factor: 5.157

10.  Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.

Authors:  N Li; K Lee; Y Xi; B Zhu; B D Gary; V Ramírez-Alcántara; E Gurpinar; J C Canzoneri; A Fajardo; S Sigler; J T Piazza; X Chen; J Andrews; M Thomas; W Lu; Y Li; D J Laan; M P Moyer; S Russo; B T Eberhardt; L Yet; A B Keeton; W E Grizzle; G A Piazza
Journal:  Oncogene       Date:  2014-04-07       Impact factor: 9.867
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  1 in total

1.  Chimeric adenoviral (Ad5.F35) and listeria vector prime-boost immunization is safe and effective for cancer immunotherapy.

Authors:  John C Flickinger; Ross E Staudt; Jagmohan Singh; Robert D Carlson; Joshua R Barton; Trevor R Baybutt; Jeffrey A Rappaport; Alicja Zalewski; Amanda Pattison; Scott A Waldman; Adam E Snook
Journal:  NPJ Vaccines       Date:  2022-06-23       Impact factor: 9.399
  1 in total

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