Lottie W Stipdonk1, Marlijne Boumeester2, Kay J Pieterman3, Marie-Christine J P Franken4, Joost van Rosmalen5, Irwin K Reiss6, Jeroen Dudink2. 1. Department of Rhinolaryngaology at Erasmus Medical University Centre-Sophia Children's Hospital, Rotterdam, Netherlands. l.stipdonk@erasmusmc.nl. 2. Division of Neonatology, Department of Pediatrics at UMCU-Wilhelmina Children's Hospital, Utrecht, Netherlands. 3. Department of Radiology at Erasmus Medical University Centre-Sophia Children's Hospital, Rotterdam, Netherlands. 4. Department of Rhinolaryngaology at Erasmus Medical University Centre-Sophia Children's Hospital, Rotterdam, Netherlands. 5. Department of Biostatistics at Erasmus Medical University Centre, Rotterdam, Netherlands. 6. Division of Neonatology, Department of Pediatrics at Erasmus Medical University Centre-Sophia Children's Hospital, Rotterdam, Netherlands.
Abstract
BACKGROUND: Volumes of cerebellar posterior lobes have been associated with cognitive skills, such as language functioning. Children born very preterm (VPT) often have language problems. However, only total cerebellar volume has been associated with language functioning, with contradicting results. The objective of this study was to ascertain whether total cerebellar structures or specific posterior lobular structures are associated with language ability of school-aged VPT children. METHODS: This is a prospective cohort study of 42 school-aged VPT children without major handicaps. Structural MRI was performed and the cerebellum segmentation pipeline was used for segmentation of separate lobules. Narrative retelling assessment was performed and language content and language structure scores were extracted. Linear regression analyses were used to associate language scores with whole gray matter (GM) cerebellar volume and right Crus I+II GM volume. RESULTS: Whole cerebellar GM volume was not significantly associated with language content nor with language structure; however, right Crus I+II GM volume was significantly associated with language content (β = 0.192 (CI = 0.033, 0.351), p = 0.020). CONCLUSIONS: GM volume of Crus I+II appears to be associated with language functions in school-aged VPT children without major handicaps, while whole cerebellar volume is not. This study showed the importance of studying cerebellar lobules separately, rather than whole cerebellar volume only, in relation to VPT children's language functions. IMPACT: GM volume of Crus I+II is associated with semantic language functions in school-aged very preterm children without overt brain injury, whereas whole cerebellar volume is not. This study showed the importance of studying cerebellar lobules separately, rather than whole cerebellar volume only, in relation to very preterm children's language functions. This study might impact future research in very preterm children. Lobular structures rather than whole cerebellar structures should be the region of interest in relation to language functions.
BACKGROUND: Volumes of cerebellar posterior lobes have been associated with cognitive skills, such as language functioning. Children born very preterm (VPT) often have language problems. However, only total cerebellar volume has been associated with language functioning, with contradicting results. The objective of this study was to ascertain whether total cerebellar structures or specific posterior lobular structures are associated with language ability of school-aged VPT children. METHODS: This is a prospective cohort study of 42 school-aged VPT children without major handicaps. Structural MRI was performed and the cerebellum segmentation pipeline was used for segmentation of separate lobules. Narrative retelling assessment was performed and language content and language structure scores were extracted. Linear regression analyses were used to associate language scores with whole gray matter (GM) cerebellar volume and right Crus I+II GM volume. RESULTS: Whole cerebellar GM volume was not significantly associated with language content nor with language structure; however, right Crus I+II GM volume was significantly associated with language content (β = 0.192 (CI = 0.033, 0.351), p = 0.020). CONCLUSIONS: GM volume of Crus I+II appears to be associated with language functions in school-aged VPT children without major handicaps, while whole cerebellar volume is not. This study showed the importance of studying cerebellar lobules separately, rather than whole cerebellar volume only, in relation to VPT children's language functions. IMPACT: GM volume of Crus I+II is associated with semantic language functions in school-aged very preterm children without overt brain injury, whereas whole cerebellar volume is not. This study showed the importance of studying cerebellar lobules separately, rather than whole cerebellar volume only, in relation to very preterm children's language functions. This study might impact future research in very preterm children. Lobular structures rather than whole cerebellar structures should be the region of interest in relation to language functions.
Authors: Jorrit F de Kieviet; Lydia Zoetebier; Ruurd M van Elburg; R Jeroen Vermeulen; Jaap Oosterlaan Journal: Dev Med Child Neurol Date: 2012-01-28 Impact factor: 5.449
Authors: Jamie Mahurin Smith; Laura Segebart DeThorne; Jessica A R Logan; Ron W Channell; Stephen A Petrill Journal: J Speech Lang Hear Res Date: 2014-06-01 Impact factor: 2.297
Authors: Gemma B Northam; Frédérique Liégeois; Jacques-Donald Tournier; Louise J Croft; Paul N Johns; Wui K Chong; John S Wyatt; Torsten Baldeweg Journal: Brain Date: 2012-11-11 Impact factor: 13.501
Authors: Soo Hyun Kwon; Dustin Scheinost; Betty Vohr; Cheryl Lacadie; Karen Schneider; Feng Dai; Gordon Sze; R Todd Constable; Laura R Ment Journal: Dev Med Child Neurol Date: 2016-03 Impact factor: 5.449