Literature DB >> 33469150

Organisational and neuromodulatory underpinnings of structural-functional connectivity decoupling in patients with Parkinson's disease.

Angeliki Zarkali1, Peter McColgan2, Louise-Ann Leyland3, Andrew J Lees4, Geraint Rees5,6, Rimona S Weil3,6,7.   

Abstract

Parkinson's dementia is characterised by changes in perception and thought, and preceded by visual dysfunction, making this a useful surrogate for dementia risk. Structural and functional connectivity changes are seen in humans with Parkinson's disease, but the organisational principles are not known. We used resting-state fMRI and diffusion-weighted imaging to examine changes in structural-functional connectivity coupling in patients with Parkinson's disease, and those at risk of dementia. We identified two organisational gradients to structural-functional connectivity decoupling: anterior-to-posterior and unimodal-to-transmodal, with stronger structural-functional connectivity coupling in anterior, unimodal areas and weakened towards posterior, transmodal regions. Next, we related spatial patterns of decoupling to expression of neurotransmitter receptors. We found that dopaminergic and serotonergic transmission relates to decoupling in Parkinson's overall, but instead, serotonergic, cholinergic and noradrenergic transmission relates to decoupling in patients with visual dysfunction. Our findings provide a framework to explain the specific disorders of consciousness in Parkinson's dementia, and the neurotransmitter systems that underlie these.

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Year:  2021        PMID: 33469150      PMCID: PMC7815846          DOI: 10.1038/s42003-020-01622-9

Source DB:  PubMed          Journal:  Commun Biol        ISSN: 2399-3642


  112 in total

1.  Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.

Authors:  Jon B Toledo; Pallavi Gopal; Kevin Raible; David J Irwin; Johannes Brettschneider; Samantha Sedor; Kayla Waits; Susana Boluda; Murray Grossman; Vivianna M Van Deerlin; Edward B Lee; Steven E Arnold; John E Duda; Howard Hurtig; Virginia M-Y Lee; Charles H Adler; Thomas G Beach; John Q Trojanowski
Journal:  Acta Neuropathol       Date:  2015-12-31       Impact factor: 17.088

2.  Fast free-form deformation using graphics processing units.

Authors:  Marc Modat; Gerard R Ridgway; Zeike A Taylor; Manja Lehmann; Josephine Barnes; David J Hawkes; Nick C Fox; Sébastien Ourselin
Journal:  Comput Methods Programs Biomed       Date:  2009-10-08       Impact factor: 5.428

3.  Depletion of cholinergic neurons in the nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies.

Authors:  Hiroshige Fujishiro; Hiroyuki Umegaki; Daisuke Isojima; Hiroyasu Akatsu; Akihisa Iguchi; Kenji Kosaka
Journal:  Acta Neuropathol       Date:  2006-01-19       Impact factor: 17.088

4.  Altered functional-structural coupling of large-scale brain networks in idiopathic generalized epilepsy.

Authors:  Zhiqiang Zhang; Wei Liao; Huafu Chen; Dante Mantini; Ju-Rong Ding; Qiang Xu; Zhengge Wang; Cuiping Yuan; Guanghui Chen; Qing Jiao; Guangming Lu
Journal:  Brain       Date:  2011-10       Impact factor: 13.501

Review 5.  Systematic review of levodopa dose equivalency reporting in Parkinson's disease.

Authors:  Claire L Tomlinson; Rebecca Stowe; Smitaa Patel; Caroline Rick; Richard Gray; Carl E Clarke
Journal:  Mov Disord       Date:  2010-11-15       Impact factor: 10.338

6.  Parkinson's Disease Society Brain Bank, London: overview and research.

Authors:  S E Daniel; A J Lees
Journal:  J Neural Transm Suppl       Date:  1993

7.  White matter microstructure deteriorates across cognitive stages in Parkinson disease.

Authors:  Tracy R Melzer; Richard Watts; Michael R MacAskill; Toni L Pitcher; Leslie Livingston; Ross J Keenan; John C Dalrymple-Alford; Tim J Anderson
Journal:  Neurology       Date:  2013-04-17       Impact factor: 9.910

8.  Discriminating cognitive status in Parkinson's disease through functional connectomics and machine learning.

Authors:  Alexandra Abós; Hugo C Baggio; Bàrbara Segura; Anna I García-Díaz; Yaroslau Compta; Maria José Martí; Francesc Valldeoriola; Carme Junqué
Journal:  Sci Rep       Date:  2017-03-28       Impact factor: 4.379

9.  Decoupling of brain function from structure reveals regional behavioral specialization in humans.

Authors:  Maria Giulia Preti; Dimitri Van De Ville
Journal:  Nat Commun       Date:  2019-10-18       Impact factor: 14.919

10.  Visual tests predict dementia risk in Parkinson disease.

Authors:  Louise-Ann Leyland; Fion D Bremner; Ribeya Mahmood; Sam Hewitt; Marion Durteste; Molly R E Cartlidge; Michelle M-M Lai; Luke E Miller; Ayse P Saygin; Pearse A Keane; Anette E Schrag; Rimona S Weil
Journal:  Neurol Clin Pract       Date:  2020-02
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  4 in total

Review 1.  Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches.

Authors:  Nicolaas I Bohnen; Alison J Yarnall; Rimona S Weil; Elena Moro; Mark S Moehle; Per Borghammer; Marc-André Bedard; Roger L Albin
Journal:  Lancet Neurol       Date:  2022-02-04       Impact factor: 44.182

2.  Deep phenotyping for precision medicine in Parkinson's disease.

Authors:  Ann-Kathrin Schalkamp; Nabila Rahman; Jimena Monzón-Sandoval; Cynthia Sandor
Journal:  Dis Model Mech       Date:  2022-06-01       Impact factor: 5.732

3.  Brain Network Topology and Structural-Functional Connectivity Coupling Mediate the Association Between Gut Microbiota and Cognition.

Authors:  Shujun Zhang; Xiaotao Xu; Qian Li; Jingyao Chen; Siyu Liu; Wenming Zhao; Huanhuan Cai; Jiajia Zhu; Yongqiang Yu
Journal:  Front Neurosci       Date:  2022-03-29       Impact factor: 4.677

4.  Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson's disease.

Authors:  Angeliki Zarkali; Andrea I Luppi; Emmanuel A Stamatakis; Suzanne Reeves; Peter McColgan; Louise-Ann Leyland; Andrew J Lees; Rimona S Weil
Journal:  Commun Biol       Date:  2022-09-08
  4 in total

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