Literature DB >> 3346867

Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors.

W P Jackson1, P J Islip, G Kneen, A Pugh, P J Wates.   

Abstract

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Year:  1988        PMID： 3346867     DOI： 10.1021/jm00398a001

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  7 in total

1.  The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C.

Authors:  S Hamid-Bloomfield; A N Payne; A A Petrovic; B J Whittle
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

2.  Pseudoperoxidase activity of 5-lipoxygenase stimulated by potent benzofuranol and N-hydroxyurea inhibitors of the lipoxygenase reaction.

Authors:  D Riendeau; J P Falgueyret; J Guay; N Ueda; S Yamamoto
Journal:  Biochem J       Date:  1991-02-15       Impact factor: 3.857

3.  Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on acute inflammatory responses.

Authors:  G A Higgs; R L Follenfant; L G Garland
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739

4.  Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: biochemical assessment in vitro and ex vivo.

Authors:  J E Tateson; R W Randall; C H Reynolds; W P Jackson; P Bhattacherjee; J A Salmon; L G Garland
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739

5.  Failure of the inhibition of rat gastric mucosal 5-lipoxygenase by novel acetohydroxamic acids to prevent ethanol-induced damage.

Authors:  N K Boughton-Smith; B J Whittle
Journal:  Br J Pharmacol       Date:  1988-09       Impact factor: 8.739

6.  BMD188, A novel hydroxamic acid compound, demonstrates potent anti-prostate cancer effects in vitro and in vivo by inducing apoptosis: requirements for mitochondria, reactive oxygen species, and proteases.

Authors:  D G Tang; L Li; Z Zhu; B Joshi; C R Johnson; L J Marnett; K V Honn; J D Crissman; S Krajewski; J C Reed; J Timar; A T Porter
Journal:  Pathol Oncol Res       Date:  1998       Impact factor: 3.201

7.  Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on bronchial anaphylaxis in anaesthetized guinea-pigs.

Authors:  A N Payne; L G Garland; I W Lees; J A Salmon
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739
  7 in total

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