Literature DB >> 33468471

Assessment of Piperacillin-Tazobactam-Meropenem Synergy against Serine Carbapenemase-Producing Enterobacterales Using Time-Kill Assays.

Alexander Lawandi1, Gleice C Leite2, Matthew P Cheng3,4, Brigitte Lefebvre5, Jean Longtin5, Todd C Lee3,6.   

Abstract

Synergy between piperacillin-tazobactam and meropenem against KPC-producing Klebsiella pneumoniae was recently demonstrated. We sought to test the combination against a broader range of serine carbapenemase producers. We tested the combination against 10 KPC-producing Escherichia coli and 10 OXA-48 family-producing K. pneumoniae isolates. Antibiotic concentrations used are achievable in critically ill patients. The combination was synergistic against 7 of 10 KPC producers and 9 of 10 OXA-48 producers. There was no synergy detected in control isolates producing NDM-1.
Copyright © 2021 American Society for Microbiology.

Entities:  

Keywords:  Enterobacterales; antimicrobial resistance; carbapenemase; meropenem; piperacillin-tazobactam; synergy; time-kill assay

Year:  2021        PMID： 33468471      PMCID： PMC8097460          DOI： 10.1128/AAC.02317-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Real-time TaqMan PCR for rapid detection of genes encoding five types of non-metallo- (class A and D) carbapenemases in Enterobacteriaceae.

Authors:  R L Swayne; H A Ludlam; V G Shet; N Woodford; M D Curran
Journal:  Int J Antimicrob Agents       Date:  2011-05-05       Impact factor: 5.283

2.  Double-carbapenem therapy for carbapenemase-producing Klebsiella pneumoniae.

Authors:  Catharine C Bulik; David P Nicolau
Journal:  Antimicrob Agents Chemother       Date:  2011-03-21       Impact factor: 5.191

3.  Rapid Detection of KPC, NDM, and OXA-48-Like Carbapenemases by Real-Time PCR from Rectal Swab Surveillance Samples.

Authors:  Tracy D Lee; Kathleen Adie; Alan McNabb; Dale Purych; Kulvinder Mannan; Robert Azana; Corrinne Ng; Patrick Tang; Linda M N Hoang
Journal:  J Clin Microbiol       Date:  2015-05-27       Impact factor: 5.948

4.  Estimating the number of infections caused by antibiotic-resistant Escherichia coli and Klebsiella pneumoniae in 2014: a modelling study.

Authors:  Elizabeth Temkin; Noga Fallach; Jonatan Almagor; Beryl Primrose Gladstone; Evelina Tacconelli; Yehuda Carmeli
Journal:  Lancet Glob Health       Date:  2018-09       Impact factor: 26.763

Review 5.  Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing.

Authors:  F C Tenover; R D Arbeit; R V Goering; P A Mickelsen; B E Murray; D H Persing; B Swaminathan
Journal:  J Clin Microbiol       Date:  1995-09       Impact factor: 5.948

6.  Comparing the Outcomes of Patients With Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae Bacteremia.

Authors:  Pranita D Tamma; Katherine E Goodman; Anthony D Harris; Tsigereda Tekle; Ava Roberts; Abimbola Taiwo; Patricia J Simner
Journal:  Clin Infect Dis       Date:  2016-11-09       Impact factor: 9.079

7.  In vitro synergy of β-lactam combinations against KPC-producing Klebsiella pneumoniae strains.

Authors:  Alexander Lawandi; Gleice Leite; Matthew P Cheng; Brigitte Lefebvre; Jean Longtin; Todd C Lee
Journal:  J Antimicrob Chemother       Date:  2019-12-01       Impact factor: 5.790

8.  Population Pharmacokinetics of High-Dose Continuous-Infusion Meropenem and Considerations for Use in the Treatment of Infections Due to KPC-Producing Klebsiella pneumoniae.

Authors:  Piergiorgio Cojutti; Assunta Sartor; Elda Righi; Claudio Scarparo; Matteo Bassetti; Federico Pea
Journal:  Antimicrob Agents Chemother       Date:  2017-09-22       Impact factor: 5.191

9.  Deaths attributable to carbapenem-resistant Enterobacteriaceae infections.

Authors:  Matthew E Falagas; Giannoula S Tansarli; Drosos E Karageorgopoulos; Konstantinos Z Vardakas
Journal:  Emerg Infect Dis       Date:  2014-07       Impact factor: 6.883

10.  Stability of Biological Activity of Frozen β-lactams over Time as Assessed by Time-Lapsed Broth Microdilutions.

Authors:  Gleice Leite; Alexander Lawandi; Matthew P Cheng; Todd Lee
Journal:  Antibiotics (Basel)       Date:  2019-09-25
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