| Literature DB >> 33468245 |
Ricardo da Cruz Lage1, Claudia Diniz Lopes Marques2, Thauana Luiza Oliveira3, Gustavo Gomes Resende4, Charles Lubianca Kohem5, Carla Gonçalves Saad6, Antônio Carlos Ximenes7, Célio Roberto Gonçalves6, Washington Alves Bianchi8, Eduardo de Souza Meirelles6, Mauro Waldemar Keiserman9, Adriano Chiereghin10, Cristiano Barbosa Campanholo11, André Marun Lyrio12, Cláudia Goldenstein Schainberg6, Lenise Brandao Pieruccetti13, Michel Alexandre Yazbek14, Penelope Esther Palominos5, Rafaela Silva Guimarães Goncalves2, Rodrigo Luppino Assad15, Rubens Bonfiglioli12, Sônia Maria Alvarenga Anti Loduca Lima16, Sueli Carneiro17, Valderílio Feijó Azevedo18, Cleandro Pires Albuquerque19, Wanderley Marques Bernardo6, Percival Degrava Sampaio-Barros6, Marcelo de Medeiros Pinheiro3.
Abstract
Spondyloarthritis (SpA) is a group of chronic inflammatory systemic diseases characterized by axial and/or peripheral joints inflammation, as well as extra-articular manifestations. Over some decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been the basis for the pharmacological treatment of patients with axial spondyloarthritis (axSpA). However, the emergence of the immunobiologic agents brought up the discussion about the role of NSAIDs in the management of these patients. The objective of this guideline is to provide recommendations for the use of NSAIDs for the treatment of axSpA. A panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis of randomized clinical trials for 15 predefined questions. The Grading of Recommendations, Assessment, Development and Evaluation methodology to assess the quality of evidence and formulate recommendations were used, and at least 70% agreement of the voting panel was needed. Fourteen recommendations for the use of NSAIDs in the treatment of patients with axSpA were elaborated. The purpose of these recommendations is to support clinicians' decision making, without taking out his/her autonomy when prescribing for an individual patient.Entities:
Keywords: Ankylosing spondylitis; Guidelines; Meta-analysis; Nonsteroidal anti-inflammatory drugs; Spondyloarthritis; Systematic review
Year: 2021 PMID: 33468245 DOI: 10.1186/s42358-020-00160-6
Source DB: PubMed Journal: Adv Rheumatol ISSN: 2523-3106