Guanghui Zheng1, Yanfei Cao2, Chunhong Liu3, Lingye Qian1, Yumeng Cai1, Miaomiao Cui4, Huiting Sun3, Lv Hong1, Jun Yuan5, Lina Zhang6, Guojun Zhang7. 1. Department of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital and Capital Medical University, NO. 119 Nansihuan West road, Fengtai district, Beijing, China. 2. Daqing Oilfield General Hospital Clinical Laboratory, No. 9 Zhongkang Street, Saltu District, Daqing, China. 3. Department of Clinical Diagnosis, Laboratory of Sanbo Brain Hospital and Capital Medical University, NO.50 Yikesong Road, Haidian District, Beijing, China. 4. Department of Clinical Diagnosis, Laboratory of the Second People's Hospital of Guiyang, Guiyang, China. 5. Department of Clinical Diagnosis, Laboratory of the Second People's Hospital of Guiyang, Guiyang, China. junyuan99430@163.com. 6. Daqing Oilfield General Hospital Clinical Laboratory, No. 9 Zhongkang Street, Saltu District, Daqing, China. zhanglina9@126.com. 7. Department of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital and Capital Medical University, NO. 119 Nansihuan West road, Fengtai district, Beijing, China. zgjlunwen@sina.com.
Abstract
BACKGROUND: To determine the phenotype, molecular characterisation and risk factors of postoperative meningitis induced by Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (EPE) in China. METHODS: We performed a multi-centre comparative cohort study of postoperative meningitis patients infected with Enterobacteriaceae in 4 neurosurgical centres in China from January 2014 to December 2019. Phenotype and molecular characteristics of the isolates were reviewed and tested, and independent risk factors of the EPE meningitis were evaluated by binary logistic regression. RESULTS: In total, 220 Enterobacteriaceae include 78 EPE were available in this study. 85.6% (67/78) ESBL-related genes were tested, and blaSHV (14.9%) and blaSHV + blaTEM + blaCTX-M-9 (20.9%) were found to be the most frequent mono and combined ESBL-related genes harboured by Enterobacteriaceae. On binary logistic analysis, craniotomy (OR. 2.583, 95% C.I. 1.274-5.235, P = 0.008) and malignancy (OR. 2.406, 95% C.I. 1.299-4.456, P = 0.005) were the associated independent risk factors to meningitis induced by EPE. CONCLUSIONS: To the best of our knowledge, this is the largest series focusing on risk factors of EPE meningitis which has been conducted in China. Craniotomy and malignancy were independent risk factors for EPE meningitis. The risk factors identified may be further utilized in clinical practice and research to avoid and reduce the mortality in future.
BACKGROUND: To determine the phenotype, molecular characterisation and risk factors of postoperative meningitis induced by Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (EPE) in China. METHODS: We performed a multi-centre comparative cohort study of postoperative meningitispatientsinfected with Enterobacteriaceae in 4 neurosurgical centres in China from January 2014 to December 2019. Phenotype and molecular characteristics of the isolates were reviewed and tested, and independent risk factors of the EPE meningitis were evaluated by binary logistic regression. RESULTS: In total, 220 Enterobacteriaceae include 78 EPE were available in this study. 85.6% (67/78) ESBL-related genes were tested, and blaSHV (14.9%) and blaSHV + blaTEM + blaCTX-M-9 (20.9%) were found to be the most frequent mono and combined ESBL-related genes harboured by Enterobacteriaceae. On binary logistic analysis, craniotomy (OR. 2.583, 95% C.I. 1.274-5.235, P = 0.008) and malignancy (OR. 2.406, 95% C.I. 1.299-4.456, P = 0.005) were the associated independent risk factors to meningitis induced by EPE. CONCLUSIONS: To the best of our knowledge, this is the largest series focusing on risk factors of EPE meningitis which has been conducted in China. Craniotomy and malignancy were independent risk factors for EPE meningitis. The risk factors identified may be further utilized in clinical practice and research to avoid and reduce the mortality in future.
Authors: Angela H A M van Hoek; Christiaan Veenman; Alice Florijn; Patricia M C Huijbers; Elisabeth A M Graat; Sabine de Greeff; Cindy M Dierikx; Engeline van Duijkeren Journal: J Antimicrob Chemother Date: 2018-12-01 Impact factor: 5.790
Authors: V Pintado; R Pazos; M E Jiménez-Mejías; A Rodríguez-Guardado; B Díaz-Pollán; C Cabellos; J M García-Lechuz; J Lora-Tamayo; P Domingo; E Muñez; D Domingo; F González-Romo; J A Lepe-Jiménez; C Rodríguez-Lucas; A Gil; I Pelegrín; F Chaves; V Pomar; A Ramos; T Alarcón; E Pérez-Cecilia Journal: J Hosp Infect Date: 2018-11-16 Impact factor: 3.926