Claudia Tonini1, Marco Segatto2, Francesca Martino1, Luisa Cigliano3, Martina Nazzaro3, Laura Barberio4, Maurizio Mandalà4, Valentina Pallottini1,5. 1. Department of Science, University Roma Tre, Viale Marconi 446, 00146 Rome, Italy. 2. Department of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, 86090 Pesche, Italy. 3. Department of Biology, University of Naples Federico II, Complesso Universitario Monte Sant'Angelo, Via Cinthia-Edificio 7, 80126 Naples, Italy. 4. Department of Biology, Ecology and Earth Science, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy. 5. Neuroendocrinology Metabolism and Neuropharmacology Unit, IRCSS Fondazione Santa Lucia, Via del Fosso Fiorano 64, 00143 Rome, Italy.
Abstract
BACKGROUND: A major problem of aging is the disruption of metabolic homeostasis. This is particularly relevant in the brain where it provokes neurodegeneration. Caloric restriction is a physiologic intervention known to delay the deleterious consequences of aging in several species ranging from yeast to mammals. To date, most studies on experimental models have started this dietary intervention from weaning, which is very difficult to be translated to human beings. Here, we study the effects of a more realistic dietary regimen in rats, starting at an advanced age and lasting for six months. METHODS: we analyzed in the cortex and hippocampus, the proteins involved in the energetic balance of the cells, cholesterol metabolism, oxidative stress response, inflammation, synaptic impairment, and brain trophism. RESULTS: our results suggest that caloric restriction in late life can revert only some age-related changes studied here.
BACKGROUND: A major problem of aging is the disruption of metabolic homeostasis. This is particularly relevant in the brain where it provokes neurodegeneration. Caloric restriction is a physiologic intervention known to delay the deleterious consequences of aging in several species ranging from yeast to mammals. To date, most studies on experimental models have started this dietary intervention from weaning, which is very difficult to be translated to human beings. Here, we study the effects of a more realistic dietary regimen in rats, starting at an advanced age and lasting for six months. METHODS: we analyzed in the cortex and hippocampus, the proteins involved in the energetic balance of the cells, cholesterol metabolism, oxidative stress response, inflammation, synaptic impairment, and brain trophism. RESULTS: our results suggest that caloric restriction in late life can revert only some age-related changes studied here.
Authors: David Vilchez; Susana Ros; Daniel Cifuentes; Lluís Pujadas; Jordi Vallès; Belén García-Fojeda; Olga Criado-García; Elena Fernández-Sánchez; Iria Medraño-Fernández; Jorge Domínguez; Mar García-Rocha; Eduardo Soriano; Santiago Rodríguez de Córdoba; Joan J Guinovart Journal: Nat Neurosci Date: 2007-10-21 Impact factor: 24.884
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