Songzhe He1,2, Shan Zhong3, Gang Liu3, Jun Yang4. 1. Clinic Laboratory Department, Affiliated Hospital of Guilin Medical University, Guilin, China. 2. Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China. 3. Department of Acupuncture, Guilin Hospital of Traditional Chinese Medicine, Guilin, China. 4. Clinic Laboratory Department, Affiliated Hospital of Guilin Medical University, Guilin, China, yangjun977534@163.com.
Abstract
BACKGROUND: Parkinson's disease (PD) is a multifactorial, chronic, and progressive neurodegenerative disease. α-Synuclein (α-syn), which is the main protein component of Lewy bodies, plays an important role in the pathological hallmarks of PD. However, the pathological function of α-syn and the molecular mechanisms responsible for the degeneration of dopaminergic neurons are still elusive. SUMMARY: Cumulative evidence implicates that abnormal processing of α-syn will be predicted to lead to pathological changes in PD. Key Messages: In this review, we summarize the structure and physiological function of α-syn, and further discuss the interplay of pathology, neuroinflammation, and environmental factors in PD. Additionally, we suggest future directions for understanding the toxicity of α-syn to neurons, which may ultimately encourage us to better design disease-modifying therapeutic strategies for PD.
BACKGROUND:Parkinson's disease (PD) is a multifactorial, chronic, and progressive neurodegenerative disease. α-Synuclein (α-syn), which is the main protein component of Lewy bodies, plays an important role in the pathological hallmarks of PD. However, the pathological function of α-syn and the molecular mechanisms responsible for the degeneration of dopaminergic neurons are still elusive. SUMMARY: Cumulative evidence implicates that abnormal processing of α-syn will be predicted to lead to pathological changes in PD. Key Messages: In this review, we summarize the structure and physiological function of α-syn, and further discuss the interplay of pathology, neuroinflammation, and environmental factors in PD. Additionally, we suggest future directions for understanding the toxicity of α-syn to neurons, which may ultimately encourage us to better design disease-modifying therapeutic strategies for PD.
Authors: Federica Piancone; Marina Saresella; Francesca La Rosa; Ivana Marventano; Mario Meloni; Jorge Navarro; Mario Clerici Journal: Front Neurosci Date: 2021-03-25 Impact factor: 4.677
Authors: Sean J Miller; Cameron E Campbell; Helen A Jimenez-Corea; Guan-Hui Wu; Robert Logan Journal: Front Neurosci Date: 2022-04-19 Impact factor: 5.152