Shlomit Kenigsberg1, Yaakov Bentov2,3,4. 1. Juno Fertility, Toronto, ON, Canada. 2. Juno Fertility, Toronto, ON, Canada. yaakov.bentov@gmail.com. 3. OBGYN Department, McMaster University, Hamilton, ON, Canada. yaakov.bentov@gmail.com. 4. OBGYN, Hadassah Mount Scopus Hospital, Hebrew University, Jerusalem, Israel. yaakov.bentov@gmail.com.
Abstract
PURPOSE: Recent publications suggested that the risk for pre-eclampsia (PE) is higher with frozen-thawed embryo transfers (FETs) compared to fresh transfers (IVF-ETs). These studies were based on old data that reflects outdated practices. In this paper, we wanted to assess the incidence of PE in current assisted reproductive technology (ART) practice. METHODS: In this cohort study, we present the incidence of PE in all births in the province of Ontario, Canada, for the years 2013-2017 for FET, IVF-ET, and natural conceptions (NC). We also compare our findings to previous studies in a meta-analysis that includes over 4 million births. RESULTS: The results of our study show that contemporary practice of ART results in comparable risk for PE between FET and IVF-ET; however, the risk is higher than NC. CONCLUSION: Current ART practice is associated with a lower risk for PE in frozen embryo transfer; this RR can be further attenuated by using ovulatory endometrial preparation for FETs.
PURPOSE: Recent publications suggested that the risk for pre-eclampsia (PE) is higher with frozen-thawed embryo transfers (FETs) compared to fresh transfers (IVF-ETs). These studies were based on old data that reflects outdated practices. In this paper, we wanted to assess the incidence of PE in current assisted reproductive technology (ART) practice. METHODS: In this cohort study, we present the incidence of PE in all births in the province of Ontario, Canada, for the years 2013-2017 for FET, IVF-ET, and natural conceptions (NC). We also compare our findings to previous studies in a meta-analysis that includes over 4 million births. RESULTS: The results of our study show that contemporary practice of ART results in comparable risk for PE between FET and IVF-ET; however, the risk is higher than NC. CONCLUSION: Current ART practice is associated with a lower risk for PE in frozen embryo transfer; this RR can be further attenuated by using ovulatory endometrial preparation for FETs.
Authors: N O'Gorman; D Wright; L C Poon; D L Rolnik; A Syngelaki; A Wright; R Akolekar; S Cicero; D Janga; J Jani; F S Molina; C de Paco Matallana; N Papantoniou; N Persico; W Plasencia; M Singh; K H Nicolaides Journal: Ultrasound Obstet Gynecol Date: 2017-05-14 Impact factor: 7.299
Authors: Sheree L Boulet; Akanksha Mehta; Dmitry M Kissin; Lee Warner; Jennifer F Kawwass; Denise J Jamieson Journal: JAMA Date: 2015-01-20 Impact factor: 56.272