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Literature DB >> 33464384

The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis.

Abstract

Obesity has been linked to an increased risk of and a worse prognosis for several types of cancer. A number of interrelated mediators contribute to obesity's pro-tumor effects, including chronic adipose inflammation and other perturbations of immune cell development and function. Here, we review studies examining the impact of obesity-induced immune dysfunction on cancer risk and progression. While the role of adipose tissue inflammation in obesity-associated cancer risk has been well characterized, the effects of obesity on immune cell infiltration and activity within the tumor microenvironment are not well studied. In this review, we aim to highlight the impact of both adipose-mediated inflammatory signaling and intratumoral immunosuppressive signaling in obesity-induced cancer risk, progression, and metastasis.

Entities: Disease

Keywords: Chemoresistance; Immunotherapy; Leptin

Mesh：

Year: 2021 PMID： 33464384 DOI： 10.1007/s00018-020-03752-z

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

218 in total

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7 in total

1. More Active Intestinal Immunity Developed by Obese Mice Than Non-Obese Mice After Challenged by Escherichia coli.

Authors: Dongjie Cai; Bin Tian; Shuang Liang; Yao Cen; Jing Fang; Xiaoping Ma; Zhijun Zhong; Zhihua Ren; Liuhong Shen; Liping Gou; Ya Wang; Zhicai Zuo
Journal: Front Vet Sci Date: 2022-06-03

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Authors: Jiming Tian; Xiaolei Liang; Dalin Wang; Jinglin Tian; Haiping Liang; Ting Lei; Zeyu Yan; Dan Wu; Xiaoli Liu; Shujuan Liu; Yongxiu Yang
Journal: Front Oncol Date: 2022-04-27 Impact factor: 5.738

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Authors: Lei Zhu; Fugui Yang; Lin Dong; Guangxue Wang; Qinchuan Li; Chunlong Zhong
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Authors: Molly Ream; Estefany Saez-Clarke; Chloe Taub; Alain Diaz; Daniela Frasca; Bonnie B Blomberg; Michael H Antoni
Journal: Front Biosci (Landmark Ed) Date: 2022-05-07