Dear Editor,We'd like to thank Jain et al.[1] contributions to our manuscript. We included 38 patients with acute central serous chorioretinopathy (CSC) with mean age of 36 years. In CSC patients, monocyte to high-density lipoprotein (HDL) ratio (MHR) was found to be higher when compared to healthy controls.[2] In the patients, MHR elevation was not assessed regarding coronary artery diseases. However, CSC might be considered as a potential risk factor for coronary artery disease in men. The cumulative incidence of 5-years coronary heart disease was found to be approximately 2-folds in CSC patients when compared to those without CSC.[3] In addition, it was reported that CSC is associated with type A personality[4] which could increase risk for cardiovascular disease even in younger ages.[5] Furthermore, Caccavele et al. reported that low-dose aspirin treatment might lead rapid visual rehabilitation and lower recurrence rate in patients with CSC. Authors suggested it is associated with platelet aggregation in choriocapillaris.[6]When cytokines are considered in CSC, Karska-Basta et al.[7] reported that plasma cytokine levels including IL-6, IL-10, IL-12 p70 were significantly increased in CSC. Authors suggested it may account for retinal and choroidal hyper-permeability. They also suggested that IL-6 is a key cytokine in the pathogenesis of CSC and there is a possible association between the inflammatory response in CSC and systemic vascular changes. Persistent increase in plasma cytokine levels were found in inflammatory disorders, history of cardiovascular disease, atherosclerosis, abdominal aortic aneurysm, varicose vein and systemic hypertension.[8] Future prospective studies may provide more comprehensive data in this issue. We'd like to thank your kind interest in our manuscript and we welcome further comments and suggestions.
Authors: Ulrich Wenzel; Jan Eric Turner; Christian Krebs; Christian Kurts; David G Harrison; Heimo Ehmke Journal: J Am Soc Nephrol Date: 2015-08-28 Impact factor: 10.121