| Literature DB >> 33462757 |
Alfarius Eko Nugroho1, Yurika Ono1, Eunji Jin1, Yusuke Hirasawa1, Toshio Kaneda1, Abdul Rahman1, Idha Kusumawati2, Takahiro Tougan3, Toshihiro Horii4, Noor Cholies Zaini2, Hiroshi Morita5.
Abstract
Two new bisindole alkaloids, 12'-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very low cytotoxic activity against a human cell line, HepG2 cells.Entities:
Keywords: Antimalarial activity; Apocynaceae; Bisindole alkaloids; Voacanga grandifolia
Year: 2021 PMID： 33462757 DOI： 10.1007/s11418-020-01475-w
Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343