| Literature DB >> 33462272 |
David K Jacobson1,2, Tanvi P Honap1,2, Andrew T Ozga3, Nicolas Meda4, Thérèse S Kagoné5, Hélène Carabin6,7,8,9, Paul Spicer2,10, Raul Y Tito2, Alexandra J Obregon-Tito2, Luis Marin Reyes11, Luzmila Troncoso-Corzo12, Emilio Guija-Poma13, Krithivasan Sankaranarayanan1,14, Cecil M Lewis15,16.
Abstract
High taxonomic diversity in non-industrial human gut microbiomes is often interpreted as beneficial; however, it is unclear if taxonomic diversity engenders ecological resilience (i.e. community stability and metabolic continuity). We estimate resilience through genus and species-level richness, phylogenetic diversity, and evenness in short-chain fatty acid (SCFA) production among a global gut metagenome panel of 12 populations (n = 451) representing industrial and non-industrial lifestyles, including novel metagenomic data from Burkina Faso (n = 90). We observe significantly higher genus-level resilience in non-industrial populations, while SCFA production in industrial populations is driven by a few phylogenetically closely related species (belonging to Bacteroides and Clostridium), meaning industrial microbiomes have low resilience potential. Additionally, database bias obfuscates resilience estimates, as we were 2-5 times more likely to identify SCFA-encoding species in industrial microbiomes compared to non-industrial. Overall, we find high phylogenetic diversity, richness, and evenness of bacteria encoding SCFAs in non-industrial gut microbiomes, signaling high potential for resilience in SCFA production, despite database biases that limit metagenomic analysis of non-industrial populations.Entities:
Mesh：
Substances：
Year: 2021 PMID： 33462272 PMCID： PMC7813856 DOI： 10.1038/s41598-021-81257-w
Source DB: PubMed Journal: Sci Rep ISSN： 2045-2322 Impact factor: 4.379