Literature DB >> 334617

The effect of short-term glucagon infusion on kidney function in normal man.

H H Parving, J Noer, H Kehlet, C E Mogensen, P A Svendsen, L Heding.   

Abstract

Kidney function was studied in six normal males before and during a 2 h glucagon (10 ng/kg/min) infusion. The following variables were determined during each 20 min clearance period; glomerular filtration rate (GFR), renal plasma-flow (RPF) , filtration fraction (FF), urinary albumin and beta2-microglobulin-excretion rates. Glucagon infusion resulted in a fourfold increase in plasma glucagon concentration. The infusion induced a significant increase in GFR (+9%), FF (+9%) and urinary beta2-microglobulin excretion rate (+32%), (p less than 0.01). RPF and urinary albumin excretion rates were not significantly changed. We suggest that glucagon may contribute to the reversible kidney function alterations typically found in poorly regulated juvenile diabetes, a state with relative or absolute hyperglucagonaemia.

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Year:  1977        PMID： 334617     DOI： 10.1007/bf01223273

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  11 in total

1.  [Effect of glucagon & insulin on kidney function, urinary excretion of phosphate, bicarbonate & ammonia ions & titratable acidity in man].

Authors:  U BUTTURINI; V BONOMINI
Journal:  Helv Med Acta       Date:  1958-11

2.  Effects of glucagon on renal function in man.

Authors:  H ELRICK; E R HUFFMAN; C J HLAD; N WHIPPLE; A STAUB
Journal:  J Clin Endocrinol Metab       Date:  1958-08       Impact factor: 5.958

3.  The effect of metabolic regulation on microvascular permeability to small and large molecules in short-term juvenile diabetics.

Authors:  H H Parving; I Noer; T Deckert; P E Evrin; S L Nielsen; J Lyngsoe; C E Mogensen; M Rorth; P A Svendsen; J Trap-Jensen; N A Lassen
Journal:  Diabetologia       Date:  1976-05       Impact factor: 10.122

4.  Radioimmunoassay of 2 -microglobulin in human biological fluids.

Authors:  P E Evrin; P A Peterson; L Wide; I Berggård
Journal:  Scand J Clin Lab Invest       Date:  1971-12       Impact factor: 1.713

5.  Impaired oxygen release caused by alterations of the metabolism in the erythrocytes in diabetes.

Authors:  J Ditzel
Journal:  Lancet       Date:  1972-04-01       Impact factor: 79.321

6.  Kidney function and glomerular permeability to macromolecules in juvenile diabetes with special reference to early changes.

Authors:  C E Mogensen
Journal:  Dan Med Bull       Date:  1972-09

7.  Radioimmunological determination of pancreatic and gut glucagon in plasma.

Authors:  L G Heding
Journal:  Diabetologia       Date:  1971-02       Impact factor: 10.122

8.  Radioimmunoassay for urinary albumin using a single antibody.

Authors:  D W Miles; C E Mogensen; H J Gundersen
Journal:  Scand J Clin Lab Invest       Date:  1970-08       Impact factor: 1.713

9.  The effect of glucagon on glomerular filtration rate in dogs during reduction of renal blood flow.

Authors:  M Levy
Journal:  Can J Physiol Pharmacol       Date:  1975-08       Impact factor: 2.273

10.  Differentiation of glomerular, tubular, and normal proteinuria: determinations of urinary excretion of beta-2-macroglobulin, albumin, and total protein.

Authors:  P A Peterson; P E Evrin; I Berggård
Journal:  J Clin Invest       Date:  1969-07       Impact factor: 14.808
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  14 in total

1.  Hyperfiltration: Much Ado about Nothing?

Authors:  Sri Lekha Tummalapalli; Michael G Shlipak
Journal:  Clin J Am Soc Nephrol       Date:  2019-05-23       Impact factor: 8.237

2.  Glucagon and ureteric colic.

Authors:  J Nepper-Rasmussen; O S Pedersen; A Andersen; J Dalsgaard
Journal:  Urol Res       Date:  1984

3.  Plasma levels and renal removal of gastrin after acute hepatic ischemia in dogs.

Authors:  A Pezzarossa; S Contini; C Scarpignato; M Bairamian; V Coiro; U Butturini
Journal:  J Endocrinol Invest       Date:  1984-06       Impact factor: 4.256

4.  The influence of age and plasma glucagon on renal clearance of 99mTc-DTPA (Sn).

Authors:  W F Sampson; M A Macleod; A S Houston
Journal:  Urol Res       Date:  1980

5.  [Behavior of the renal functional reserve in type I diabetic patients: effect of ACE-inhibition].

Authors:  T Eisenhauer; E Jungmann; D Warneboldt; G Ansorge; J Scherberich; J Talartschik
Journal:  Klin Wochenschr       Date:  1990-08-02

Review 6.  An approach to protein restriction in children with renal insufficiency.

Authors:  N G Raymond; J T Dwyer; P Nevins; P Kurtin
Journal:  Pediatr Nephrol       Date:  1990-03       Impact factor: 3.714

7.  [Loss of renal functional reserve following kidney transplantation and in patients with advanced disorders of liver function].

Authors:  T Eisenhauer; J Talartschik; H Hartmann; E Quentin; F Scheler
Journal:  Klin Wochenschr       Date:  1988-09-15

8.  The glomerular hyperfiltration of diabetes is not associated with elevated plasma levels of glucagon and growth hormone.

Authors:  M J Wiseman; S Redmond; F House; H Keen; G C Viberti
Journal:  Diabetologia       Date:  1985-10       Impact factor: 10.122

Review 9.  Early functional and morphologic vascular renal consequences of the diabetic state.

Authors:  C E Mogensen; R Osterby; H J Gundersen
Journal:  Diabetologia       Date:  1979-08       Impact factor: 10.122

10.  The effect of glucagon infusion on kidney function in short-term insulin-dependent juvenile diabetics.

Authors:  H H Parving; J S Christiansen; I Noer; B Tronier; C E Mogensen
Journal:  Diabetologia       Date:  1980-10       Impact factor: 10.122
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