| Literature DB >> 33460581 |
Sujay Paul1, Luis M Ruiz-Manriquez2, S Janin Ledesma-Pacheco2, Javier A Benavides-Aguilar2, Andrea Torres-Copado2, Jonathan I Morales-Rodríguez2, Marcos De Donato2, Aashish Srivastava3.
Abstract
MicroRNAs (miRNAs) are small non-coding highly conserved RNA molecules that can act as master regulators of gene expression in a sequence-specific manner either by translation repression or mRNA degradation, influencing a wide range of biologic processes that are essential for the maintenance of cellular homeostasis. Chronic pediatric diseases are the leading cause of death worldwide among children and the recent evidence indicates that aberrant miRNA expression significantly contributes to the development of chronic pediatric diseases. This review focuses on the role of miRNAs in five major chronic pediatric diseases including bronchial asthma, congenital heart diseases, cystic fibrosis, type 1 diabetes mellitus, and epilepsy, and their potential use as novel biomarkers for the diagnosis and prognosis of these disorders.Entities:
Keywords: Bronchial asthma; Congenital heart disease; Cystic fibrosis; Epilepsy; Type 1 diabetes mellitus; microRNA biomarker
Year: 2021 PMID: 33460581 DOI: 10.1016/j.abb.2021.108763
Source DB: PubMed Journal: Arch Biochem Biophys ISSN: 0003-9861 Impact factor: 4.013