Literature DB >> 33459785

Nebulosa recovers single cell gene expression signals by kernel density estimation.

Jose Alquicira-Hernandez1,2, Joseph E Powell1,3.   

Abstract

SUMMARY: Data sparsity in single-cell experiments prevents an accurate assessment of gene expression when visualised in a low-dimensional space. Here, we introduce Nebulosa, an R package that uses weighted kernel density estimation to recover signals lost through drop-out or low expression.
AVAILABILITY AND IMPLEMENTATION: Nebulosa can be easily installed from www.github.com/powellgenomicslab/Nebulosa. SUPPLEMENTARY INFORMATION: Supplementary data are available online.
© The Author(s) (2021). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Year:  2021        PMID: 33459785     DOI: 10.1093/bioinformatics/btab003

Source DB:  PubMed          Journal:  Bioinformatics        ISSN: 1367-4803            Impact factor:   6.937


  15 in total

1.  A growth factor-expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15.

Authors:  Andreas Patsalos; Laszlo Halasz; Miguel A Medina-Serpas; Wilhelm K Berger; Bence Daniel; Petros Tzerpos; Máté Kiss; Gergely Nagy; Cornelius Fischer; Zoltan Simandi; Tamas Varga; Laszlo Nagy
Journal:  J Exp Med       Date:  2021-11-30       Impact factor: 14.307

2.  IL-17A-producing γδT cells promote muscle regeneration in a microbiota-dependent manner.

Authors:  Alexander O Mann; Bola S Hanna; Andrés R Muñoz-Rojas; Inga Sandrock; Immo Prinz; Christophe Benoist; Diane Mathis
Journal:  J Exp Med       Date:  2022-04-05       Impact factor: 14.307

3.  Noncanonical activation of GLI signaling in SOX2+ cells drives medulloblastoma relapse.

Authors:  Marzena Swiderska-Syn; Júlia Mir-Pedrol; Alexander Oles; Olga Schleuger; April D Salvador; Sean M Greiner; Cara Seward; Fan Yang; Benjamin R Babcock; Chen Shen; Daniel T Wynn; Avencia Sanchez-Mejias; Timothy R Gershon; Vanesa Martin; Heather J McCrea; Kathryn G Lindsey; Carsten Krieg; Jezabel Rodriguez-Blanco
Journal:  Sci Adv       Date:  2022-07-20       Impact factor: 14.957

4.  Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells.

Authors:  Samuel W Lukowski; Inga Rødahl; Samuel Kelly; Meihua Yu; James Gotley; Chenhao Zhou; Susan Millard; Stacey B Andersen; Angelika N Christ; Gabrielle Belz; Ian H Frazer; Janin Chandra
Journal:  iScience       Date:  2021-04-15

5.  Single-Cell Transcriptomics Reveals the Expression of Aging- and Senescence-Associated Genes in Distinct Cancer Cell Populations.

Authors:  Dominik Saul; Robyn Laura Kosinsky
Journal:  Cells       Date:  2021-11-11       Impact factor: 6.600

6.  Modulation of fracture healing by the transient accumulation of senescent cells.

Authors:  Dominik Saul; David G Monroe; Jennifer L Rowsey; Robyn Laura Kosinsky; Stephanie J Vos; Madison L Doolittle; Joshua N Farr; Sundeep Khosla
Journal:  Elife       Date:  2021-10-07       Impact factor: 8.140

7.  Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes.

Authors:  Chandan Sona; Yu-Te Yeh; Andreas Patsalos; Laszlo Halasz; Xin Yan; Natalia L Kononenko; Laszlo Nagy; Matthew N Poy
Journal:  JCI Insight       Date:  2022-03-22

8.  Multidimensional Single-Nuclei RNA-Seq Reconstruction of Adipose Tissue Reveals Adipocyte Plasticity Underlying Thermogenic Response.

Authors:  Carlos Alberto Oliveira Biagi; Sarah Santiloni Cury; Cleidson Pádua Alves; Nabil Rabhi; Wilson Araujo Silva; Stephen R Farmer; Robson Francisco Carvalho; Miguel Luiz Batista
Journal:  Cells       Date:  2021-11-08       Impact factor: 6.600

9.  Integrated analysis of multimodal single-cell data.

Authors:  Yuhan Hao; Stephanie Hao; Erica Andersen-Nissen; William M Mauck; Shiwei Zheng; Andrew Butler; Maddie J Lee; Aaron J Wilk; Charlotte Darby; Michael Zager; Paul Hoffman; Marlon Stoeckius; Efthymia Papalexi; Eleni P Mimitou; Jaison Jain; Avi Srivastava; Tim Stuart; Lamar M Fleming; Bertrand Yeung; Angela J Rogers; Juliana M McElrath; Catherine A Blish; Raphael Gottardo; Peter Smibert; Rahul Satija
Journal:  Cell       Date:  2021-05-31       Impact factor: 41.582

10.  rPanglaoDB: an R package to download and merge labeled single-cell RNA-seq data from the PanglaoDB database.

Authors:  Daniel Osorio; Marieke L Kuijjer; James J Cai
Journal:  Bioinformatics       Date:  2021-07-28       Impact factor: 6.937

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