| Literature DB >> 33459710 |
Andrée-Ann Baril1,2, Alexa S Beiser1,2,3, Susan Redline4,5,6, Emer R McGrath1,7, Daniel J Gottlieb4,6,8, Hugo Aparicio1,2, Sudha Seshadri1,2,9, Jayandra J Himali1,2,3,9,10, Matthew P Pase1,11,12.
Abstract
Because of their roles as potential risk factors, we evaluated whether obstructive sleep apnea (OSA) severity interacts with interleukin-6 (IL-6) in predicting incident dementia of the Alzheimer's type (DAT). In 269 dementia-free participants, IL-6 and the apnea-hypopnea index (AHI) were measured at baseline and incident DAT was surveilled for up to 22.8 years. Cox models revealed a significant interaction: In the lowest IL-6 quartile only, a higher AHI was associated with an elevated risk of DAT. The association between OSA severity and incident DAT might be especially apparent in the absence of inflammation or absence of potential benefits from IL-6.Entities:
Keywords: Alzheimer’s disease; dementia; inflammation; interleukin-6; sleep apnea; sleep disorders; sleep-disordered breathing
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Year: 2021 PMID： 33459710 PMCID： PMC8803404 DOI： 10.3233/JAD-200545
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472