Literature DB >> 33459116

Role of Aurora B and Haspin kinases in the metaphase Topoisomerase II checkpoint.

M Johansson1, Y Azuma2, D J Clarke1.   

Abstract

DNA Topoisomerase II (TopoII) uses ATP hydrolysis to decatenate chromosomes so that sister chromatids can faithfully segregate in mitosis. When the TopoII enzyme cycle stalls due to failed ATP hydrolysis, the onset of anaphase is delayed, presumably to allow extra time for decatenation to be completed. Recent evidence revealed that, unlike the spindle assembly checkpoint, this TopoII checkpoint response requires Aurora B and Haspin kinases and is triggered by SUMOylation of the C-terminal domain of TopoII.

Entities:  

Keywords:  Aurora B; Haspin; Topoisomerase II; checkpoint; mitosis

Mesh：

Substances：

Year:  2021        PMID： 33459116      PMCID： PMC7894448          DOI： 10.1080/15384101.2021.1875671

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  32 in total

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