| Literature DB >> 33458860 |
Chao-Chun Yang1,2, Chin-Han Wu3, Tak-Wah Wong1,4, Feng-Jie Lai5, Kai-Che Wei6, Tzu-Kai Lin7, Chrang-Shi Lin8, Juemin Zhao9, Leihong Xiang9, Chao-Hsing Kao10, Ying-Jan Wang11, Cheng-Che Eric Lan12, Hamm-Ming Sheu10.
Abstract
SR-T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B-induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR-T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16-week SR-T100 gel treatment were documented. SR-T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR-T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR-T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR-T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.Entities:
Keywords: zzm321990Solanum undatumzzm321990; actinic keratosis; photoaging; photocarcinogenesis; solamargine
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Year: 2021 PMID： 33458860 DOI： 10.1111/1346-8138.15703
Source DB: PubMed Journal: J Dermatol ISSN： 0385-2407 Impact factor: 4.005