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Literature DB >> 3345839

Primary structure of the site on bovine hormone-sensitive lipase phosphorylated by cyclic AMP-dependent protein kinase.

A J Garton¹, D G Campbell, P Cohen, S J Yeaman.

Abstract

The primary structure of a region on hormone-sensitive lipase was determined to be: Lys-Thr-Glu-Pro-Met-Arg-Arg-Ser- Val-Ser-Glu-Ala-Ala-Leu-Thr-Gln-Pro-Glu-Gly-Pro-Leu-Gly-Thr-Asp-Ser-Leu-Lys. Ser-8 was the only residue in the intact protein phosphorylated by cyclic AMP-dependent protein kinase. However, Ser-10 also appeared to be present in a phosphorylated form, suggesting that it is a target for a distinct protein kinase in vivo.

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Year: 1988 PMID： 3345839 DOI： 10.1016/0014-5793(88)80799-3

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

27 in total

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Authors: Ghada A Soliman; Hugo A Acosta-Jaquez; Diane C Fingar
Journal: Lipids Date: 2010-11-02 Impact factor: 1.880

2. Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient mice.

Authors: Genevieve Marcelin; Shun-Mei Liu; Xiaosong Li; Gary J Schwartz; Streamson Chua
Journal: J Lipid Res Date: 2012-03-01 Impact factor: 5.922

3. Protein kinase a-dependent phosphorylation of serine 119 in the proto-oncogenic serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein.

Authors: Anne Kristin Aksaas; Sissel Eikvar; Göran Akusjärvi; Bjørn S Skålhegg; Anne Katrine Kvissel
Journal: Genes Cancer Date: 2011-08

4. Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells.

Authors: Natasha C Lucki; Donghui Li; Marion B Sewer
Journal: Mol Cell Endocrinol Date: 2011-08-16 Impact factor: 4.102

5. Widdrol-induced lipolysis is mediated by PKC and MEK/ERK in 3T3-L1 adipocytes.

Authors: Hyun Young Jeong; Hee Jung Yun; Byung Woo Kim; Eun Woo Lee; Hyun Ju Kwon
Journal: Mol Cell Biochem Date: 2015-09-10 Impact factor: 3.396

6. Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet.

Authors: J J Egan; A S Greenberg; M K Chang; S A Wek; M C Moos; C Londos
Journal: Proc Natl Acad Sci U S A Date: 1992-09-15 Impact factor: 11.205

Primary structure of the site on bovine hormone-sensitive lipase phosphorylated by cyclic AMP-dependent protein kinase.

1. mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes.

2. Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient mice.

3. Protein kinase a-dependent phosphorylation of serine 119 in the proto-oncogenic serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein.

4. Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells.

5. Widdrol-induced lipolysis is mediated by PKC and MEK/ERK in 3T3-L1 adipocytes.

6. Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet.

Review 7. Hormone-sensitive lipase--new roles for an old enzyme.

8. Spatiotemporal regulation of early lipolytic signaling in adipocytes.

9. Overexpression of hormone-sensitive lipase prevents triglyceride accumulation in adipocytes.

10. The presence and role of hormone-sensitive lipase in heart muscle.