BACKGROUND AND PURPOSE: Magnetic resonance imaging (MRI)-guided focal salvage high-dose-rate brachytherapy (FS-HDR-BT) is one of the treatment options for radiorecurrent localized prostate cancer. However, due to the invasive nature of the treatment, not all patients are eligible. Magnetic resonance linear accelerator (MR-Linac) systems open up new treatment possibilities and could potentially replace FS-HDR-BT treatment. We conducted a planning study to investigate the feasibility of delivering a single 19 Gy dose to the recurrent lesion using a 1.5 Tesla MR-Linac system. MATERIALS AND METHODS: Thirty patients who underwent FS-HDR-BT were included. The clinical target volume (CTV) encompassed the visible lesion plus a 5 mm margin. Treatment plans were created for a 1.5 Tesla MR-Linac system using a 1 mm planning target volume (PTV) margin. A dose of 19 Gy was prescribed to ≥ 95% of the PTV. In case this target could not be reached, i.e. when organs-at-risk (OAR) constraints were violated, a dose of ≥ 17 Gy to ≥ 90% of the PTV was accepted. MR-Linac plans were compared to clinical FS-HDR-BT plans. RESULTS: Target dose coverage was achieved in 14/30 (47%) FS-HDR-BT plans and 17/30 (57%) MR-Linac plans, with comparable median D95% and D90%. In FS-HDR-BT plans, a larger volume reached ≥ 150% of the prescribed dose. Urethra D10%, rectum D1cm3, and rectum D2cm3 were lower in the FS-HDR-BT plans, while bladder dose was comparable for both modalities. CONCLUSION: Single fraction treatment of recurrent prostate cancer lesions may be feasible using stereotactic body radiotherapy (SBRT) on a MR-Linac system.
BACKGROUND AND PURPOSE: Magnetic resonance imaging (MRI)-guided focal salvage high-dose-rate brachytherapy (FS-HDR-BT) is one of the treatment options for radiorecurrent localized prostate cancer. However, due to the invasive nature of the treatment, not all patients are eligible. Magnetic resonance linear accelerator (MR-Linac) systems open up new treatment possibilities and could potentially replace FS-HDR-BT treatment. We conducted a planning study to investigate the feasibility of delivering a single 19 Gy dose to the recurrent lesion using a 1.5 Tesla MR-Linac system. MATERIALS AND METHODS: Thirty patients who underwent FS-HDR-BT were included. The clinical target volume (CTV) encompassed the visible lesion plus a 5 mm margin. Treatment plans were created for a 1.5 Tesla MR-Linac system using a 1 mm planning target volume (PTV) margin. A dose of 19 Gy was prescribed to ≥ 95% of the PTV. In case this target could not be reached, i.e. when organs-at-risk (OAR) constraints were violated, a dose of ≥ 17 Gy to ≥ 90% of the PTV was accepted. MR-Linac plans were compared to clinical FS-HDR-BT plans. RESULTS: Target dose coverage was achieved in 14/30 (47%) FS-HDR-BT plans and 17/30 (57%) MR-Linac plans, with comparable median D95% and D90%. In FS-HDR-BT plans, a larger volume reached ≥ 150% of the prescribed dose. Urethra D10%, rectum D1cm3, and rectum D2cm3 were lower in the FS-HDR-BT plans, while bladder dose was comparable for both modalities. CONCLUSION: Single fraction treatment of recurrent prostate cancer lesions may be feasible using stereotactic body radiotherapy (SBRT) on a MR-Linac system.
Authors: Anders Widmark; Adalsteinn Gunnlaugsson; Lars Beckman; Camilla Thellenberg-Karlsson; Morten Hoyer; Magnus Lagerlund; Jon Kindblom; Claes Ginman; Bengt Johansson; Kirsten Björnlinger; Mihajl Seke; Måns Agrup; Per Fransson; Björn Tavelin; David Norman; Björn Zackrisson; Harald Anderson; Elisabeth Kjellén; Lars Franzén; Per Nilsson Journal: Lancet Date: 2019-06-18 Impact factor: 79.321
Authors: Gijsbert H Bol; Alexis N T J Kotte; Uulke A van der Heide; Jan J W Lagendijk Journal: Comput Methods Programs Biomed Date: 2009-05-13 Impact factor: 5.428
Authors: D M de Muinck Keizer; A U Pathmanathan; A Andreychenko; L G W Kerkmeijer; J R N van der Voort van Zyp; A C Tree; C A T van den Berg; J C J de Boer Journal: Phys Med Biol Date: 2019-04-04 Impact factor: 3.609
Authors: D M de Muinck Keizer; L G W Kerkmeijer; T Willigenburg; A L H M W van Lier; M D den Hartogh; J R N van der Voort van Zyp; E N de Groot-van Breugel; B W Raaymakers; J J W Lagendijk; J C J de Boer Journal: Radiother Oncol Date: 2020-07-03 Impact factor: 6.280
Authors: D M de Muinck Keizer; L G W Kerkmeijer; M Maspero; A Andreychenko; J R N van der Voort van Zyp; C A T van den Berg; B W Raaymakers; J J W Lagendijk; J C J de Boer Journal: Phys Med Biol Date: 2019-12-05 Impact factor: 3.609
Authors: Metha Maenhout; Max Peters; Marco van Vulpen; Marinus A Moerland; Richard P Meijer; Maurice A A J van den Bosch; Paul L Nguyen; Steven J Frank; Jochem R N van der Voort van Zyp Journal: Technol Cancer Res Treat Date: 2017-12-05