Literature DB >> 33457479

Metabolomic analysis data of MPP+-exposed SH-SY5Y cells using CE-TOFMS.

Taku Amo1, Yutaka Oji2, Shinji Saiki2, Nobutaka Hattori2.   

Abstract

1-Methyl-4-phenylpyridinium (MPP+)-treated human neuroblastoma SH-SY5Y cells have been generally accepted as a cellular model for Parkinson's disease. This article contains metabolic analysis data of not only cell lysate but also culture supernatants to understand comprehensive metabolic disturbances in this model. Metabolic analysis employed by capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). Data obtained by CE-TOFMS were processed to extract peak information including m/z, peak area, and migration time. The data provided in this manuscript have been analyzed and discussed in the research article entitled "Metabolomic analysis revealed mitochondrial dysfunction and aberrant choline metabolism in MPP+-exposed SH-SY5Y cells" [1].
© 2021 The Authors. Published by Elsevier Inc.

Entities:  

Keywords:  CE-TOFMS; MPP+; Metabolome; Mitochondria; Parkinson's disease; SH-SY5Y

Year:  2020        PMID: 33457479      PMCID: PMC7797368          DOI: 10.1016/j.dib.2020.106707

Source DB:  PubMed          Journal:  Data Brief        ISSN: 2352-3409


  5 in total

1.  Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia.

Authors:  Takushi Ooga; Hajime Sato; Atsushi Nagashima; Kazunori Sasaki; Masaru Tomita; Tomoyoshi Soga; Yoshiaki Ohashi
Journal:  Mol Biosyst       Date:  2011-01-24

2.  Metabolomic analysis revealed mitochondrial dysfunction and aberrant choline metabolism in MPP+-exposed SH-SY5Y cells.

Authors:  Taku Amo; Yutaka Oji; Shinji Saiki; Nobutaka Hattori
Journal:  Biochem Biophys Res Commun       Date:  2019-09-16       Impact factor: 3.575

3.  Depiction of metabolome changes in histidine-starved Escherichia coli by CE-TOFMS.

Authors:  Yoshiaki Ohashi; Akiyoshi Hirayama; Takamasa Ishikawa; Seira Nakamura; Kaori Shimizu; Yuki Ueno; Masaru Tomita; Tomoyoshi Soga
Journal:  Mol Biosyst       Date:  2007-11-15

4.  A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Authors:  R S Burns; C C Chiueh; S P Markey; M H Ebert; D M Jacobowitz; I J Kopin
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

Review 5.  The SH-SY5Y cell line in Parkinson's disease research: a systematic review.

Authors:  Helena Xicoy; Bé Wieringa; Gerard J M Martens
Journal:  Mol Neurodegener       Date:  2017-01-24       Impact factor: 14.195

  5 in total

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